Preconception menstrual cycle disorder and antenatal depression: a cross-sectional study with prerecorded information.
Preconception menstrual cycle disorder and antenatal depression: a cross-sectional study with prerecorded information.
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孕前月经周期紊乱和产前抑郁症：一项预先记录信息的横断面研究。
DOI：
10.1080/0167482x.2021.2010699
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Nishi D.
中科院分区：
文献类型：
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作者：
Sasaki N;Akiyama H;Kawakami N;Nishi D.
目的本研究旨在评估妊娠前月经周期特征之间的相关性（即周期长度变异性和周期长度）和产前抑郁症。方法本研究检索了使用妊娠跟踪应用程序的16-20周孕妇的随机对照试验的基线调查数据。使用爱丁堡产后抑郁量表（EPDS）评估产前抑郁症。妊娠16-20周，以10/11为分界点。通过预先记录的月经周期跟踪应用程序获得受孕前月经周期信息。周期长度变异性定义为周期之间长度的平均差异，分为规则（≤6天）和不规则（>6天）。周期长度编码为分类变量：<25天、25-26天、27-29天（常规）、30-31天、32-33天和34+天。使用回归分析和多元Logistic回归模型调整协variates.ResultsThe共3473名参与者在这项研究中进行了分析的协会与EPDS评分的周期障碍。不规则的月经周期（>6天）与EPDS高评分（校正后：标准化beta = 0.049，p = 0.003）和EPDS高截止评分（> 11）显著相关（校正后OR = 1.40 [1.02-1.94]，p= 0.038），但与周期长度无关。需要进一步探讨孕前月经周期的健康状况，以促进健康的孕产妇心理健康。
ObjectivesThis study aimed to evaluate the association between pre-pregnancy menstrual cycle characteristics (i.e. cycle-length variability and cycle length) and antenatal depression.MethodsThis study retrieved the data from the baseline survey of the randomized controlled trial with pregnant women at 16–20 weeks gestation who used a pregnancy tracking app. The antenatal depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS) at 16–20 weeks gestation, and the cutoff point of 10/11 was adopted. Pre-conceptional menstrual cycle information was obtainedviaa prerecorded period tracking app. Cycle-length variability was defined as the average difference in the lengths between cycles, dichotomized into regular (≤6 days) and irregular (>6 days). Cycle length was coded as a categorical variable: <25 days, 25–26 days, 27–29 days (regular), 30–31 days, 32–33 days, and 34+ days. The associations of cycle disorders with EPDS scores were examined using regression analysis and a multiple logistic regression model adjusted for covariates.ResultsThe total of 3473 participants were analyzed in this study. Irregular cycle variability (>6 days) was significantly associated with high EPDS scores (adjusted: standardized beta = 0.049,p= 0.003) and with high cutoff EPDS scores (over 11) (adjusted OR = 1.40 [1.02–1.94],p= 0.038) but not with cycle length.ConclusionIrregular menstrual cycle before pregnancy was associated with depression during pregnancy. The health of the menstrual cycle during preconception needs to be further explored to promote healthy maternal mental health.