Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium.
Calcium inhibits the damaging and compensatory proliferative effects of fatty acids on mouse colon epithelium.
复制标题
钙抑制脂肪酸对小鼠结肠上皮的破坏性和代偿性增殖作用。
DOI：
10.1016/0304-3835(84)90091-0
复制
发表时间：
1984
期刊：
影响因子：
9.7
通讯作者：
H. Newmark
中科院分区：
文献类型：
--
作者：
M. Wargovich;V. Eng;H. Newmark
脂肪酸（FA）、月桂酸、亚油酸或油酸的直肠内滴注可诱导结肠上皮的炎症和浅表溶解。该反应之后是结肠有丝分裂活性的增加和参与DNA合成的细胞数量的增加，以补偿失去的细胞的再生。这在一定程度上解释了膳食脂肪在致癌作用中的促进作用。同时口服钙盐，如碳酸钙，大大降低了脂肪酸对结肠上皮细胞的促有丝分裂作用，可能是通过形成生物惰性钙皂。膳食脂肪酸的钙皂形成可能是结肠上皮细胞受到保护的一种自然机制，因此减少了膳食脂肪对该器官致癌作用的影响。
Intrarectal instillations of the fatty acids (FA), lauric, linoleic or oleic acids induce inflammation and superficial lysis of the colon epithelium. This reaction is followed by increases in colonic mitotic activity and the number of cells engaged in DNA synthesis in compensatory regeneration for the cells that were lost. This explains, in part, the promotional effect of dietary fat in carcinogenesis. Concomitant oral administration of calcium salts, as CaCO3, largely reduced the mitogenic effects of fatty acids on colon epithelium, presumably by forming biologically inert calcium soaps. Calcium soap formation of dietary fatty acids may be one natural mechanism by which colon epithelium cells are protected hence reducing the impact of dietary fat on carcinogenesis for this organ.