Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.
Increased prevalence of cerebral microbleeds in patients with low left ventricular systolic function.
复制标题
左心室收缩功能低下的患者脑微出血的发生率增加。
DOI：
10.1007/s00380-019-01503-0
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hoshiga M.
中科院分区：
文献类型：
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作者：
Watanabe T;Kanzaki Y;Yamauchi Y;Ito T;Nishida Y;Yamamura K;Komori T;Sohmiya K;Hoshiga M.
梯度回声T2星（T2*）加权磁共振成像（MRI）是一种检测脑微出血（CMBs）的灵敏方法。据报道，CMBs的存在是未来心血管死亡率的一个标志，并与各种心血管危险因素、抗血栓药物的使用和认知功能障碍有关。然而，心功能与CMBs之间的关系尚不清楚。我们研究了心血管疾病患者心功能与CMBs存在之间的关系。这项单中心回顾性研究共纳入424名参与者(平均年龄70±12岁；男性286人（67%）；平均左室射血分数（LVEF） 61%±12%]，1个月内接受超声心动图和脑T2*加权MRI检查，无神经异常。118例（28%）患者发现CMBs。CMBs与抗凝或抗血小板治疗无显著相关性。有CMBs的患者LVEF明显低于无CMBs的患者（59%±13% vs. 62%±11%，P< 0.05）。多因素logistic分析显示，较低的LVEF[比值比（OR） 0.98, 95%可信区间（CI） 0.96-1.00， P< 0.05]和年龄（OR 1.02, 95% CI 1.00-1.05， P< 0.05）与CMBs显著相关。CMBs的存在常见于心血管疾病患者，并与年龄和LVEF显著相关。
Gradient-echo T2-star (T2*)-weighted magnetic resonance imaging (MRI) is a sensitive method to detect cerebral microbleeds (CMBs). The presence of CMBs was reported to be a marker of future cardiovascular mortality and is associated with various cardiovascular risk factors, use of antithrombotic drugs, and cognitive dysfunction. However, the relationship between cardiac function and CMBs remains unclear. We investigated the association between cardiac function and presence of CMBs in patients with cardiovascular diseases. This single-center retrospective study included a total of 424 participants (mean age 70 ± 12 years; men 286 (67%); mean left ventricular ejection fraction (LVEF) 61% ± 12%] who underwent echocardiography and brain T2*-weighted MRI within 1 month without neurologic abnormality. CMBs were found in 118 (28%) patients. There was no significant relationship between CMBs and anticoagulant or antiplatelet therapy. LVEF was significantly lower in patients with CMBs than in those without CMBs (59% ± 13% vs. 62% ± 11%,P< 0.05). On multivariate logistic analysis, lower LVEF [odds ratio (OR) 0.98, 95% confidence interval (CI) 0.96–1.00;P< 0.05] and age (OR 1.02, 95% CI 1.00–1.05;P< 0.05) were significantly associated with CMBs. The presence of CMBs was frequently observed in the patients with cardiovascular disease and was significantly associated with age and LVEF.