MET exon 14 skipping is overexpressed in an allele-specific manner in lung adenocarcinoma primary samples.
MET exon 14 skipping is overexpressed in an allele-specific manner in lung adenocarcinoma primary samples.
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DOI：
10.17912/micropub.biology.000957
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发表时间：
2023
影响因子：
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通讯作者：
Brooks, Angela N
中科院分区：
文献类型：
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作者：
Durham, Megan;Vadde, Swetha;Brooks, Angela N
MET 外显子 14 跳跃 (METΔ14) 是 Ras-MAPK 通路中驱动肺腺癌 (LUAD) 的一个明确表征的癌基因。之前对 METΔ14 的研究表明，这种异常剪接的癌基因在 LUAD 原代样本中表达，并与外显子 14 剪接位点附近的杂合体细胞突变和缺失相关。通过进一步检查原始样本的 DNA 和 RNA 测序数据，我们强调 METΔ14 以等位基因特异性方式过度表达。这些数据表明 METΔ14 的剂量依赖性可能对肿瘤发生至关重要。
MET exon 14 skipping ( METΔ14 ) is a well-characterized oncogene in the Ras-MAPK pathway driving lung adenocarcinoma (LUAD). Previous studies on METΔ14 revealed this aberrantly spliced oncogene is expressed in LUAD primary samples and is associated with heterozygous somatic mutations and deletions near exon 14 splice sites. Upon further examination of DNA and RNA sequencing data from primary samples, we highlight that METΔ14 is overexpressed in an allele-specific manner. These data suggest that dose-dependence of METΔ14 may be critical to oncogenesis.