Preparation, 195Pt NMR spectra and biological activity of platinum (IV) complexes with dipeptides.
Preparation, 195Pt NMR spectra and biological activity of platinum (IV) complexes with dipeptides.
复制标题
铂(IV)二肽配合物的制备、195Pt NMR谱及生物活性。
DOI：
10.1016/s0162-0134(98)10084-3
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发表时间：
1999
影响因子：
3.9
通讯作者：
M. Suzuki
中科院分区：
文献类型：
--
作者：
M. Watabe;T. Kobayashi;T. Kawahashi;A. Hino;T. Watanabe;T. Mikami;T. Matsumoto;M. Suzuki
合成了三种K[Pt（IV）（dipep）Cl（OH）2]型二肽配合物和四种K[Pt（IV）-（Hdipep）Cl 2（OH）2]型二肽配合物。K[Pt（IV）（dipep）Cl（OH）2]配合物的~（195）Pt NMR谱峰出现在1200 ppm附近，与K[Pt（II）（dipep）Cl]配合物相比，其化学位移约为3150 ppm。K[Pt（IV）（Hdipep）Cl 2（OH）2]络合物的化学位移为约900 ppm，即，与K[Pt（II）（Hdipep）Cl]配合物相比，低场约3050 ppm。H[Pt（IV）（Hdigly）Cl 2（OH）2]和K[Pt（IV）（Hdigly）Cl 2（OH）2]配合物抑制了C.顺铂浓度为1 μg/ml时，铂配合物对白色念珠菌的抑制作用比顺铂浓度为1 μg/ml时更弱，但对Meth-A和Hep-2细胞的抑制作用比顺铂浓度为10 μg/ml时更弱。这些结果表明，铂配合物选择性地抑制真菌细胞的生长。
Three dipeptide complexes of the form K[Pt(IV)(dipep)Cl(OH)2] and four dipeptide complexes of the form K[Pt(IV)-(Hdipep)Cl2(OH)2] were newly prepared. The195Pt NMR peaks of the K[Pt(IV) (dipep) Cl(OH)2] complexes appeared at about 1200 ppm and these chemical shifts were about 3150 ppm downfield compared with those of the K[Pt(II)(dipep)Cl] complexes. The chemical shifts of the K[Pt(IV)(Hdipep)Cl2(OH)2] complexes were at about 900 ppm, i.e., about 3050 ppm downfield compared with those of the K[Pt(II)(Hdipep)Cl] complexes. The H[Pt(IV)(Hdigly)Cl2(OH)2] and K[Pt(IV)(Hdigly)Cl2(OH)2] complexes inhibited the growth of C. albicans at a more diluted concentration than cisplatin at 1 μg/ml, but the platinum complexes only weakly inhibited the growth of these cells compared with the cisplatin-inhibited growth of Meth-A and Hep-2 cells at 10 μg/ml. These results suggested that the platinum complexes selectively inhibited the growth of fungal cells.
影响因子：
56.9
作者：
PIL, PM;LIPPARD, SJ
通讯作者：
LIPPARD, SJ