Research Progress and Challenges in the Treatment of Central Nervous System Metastasis of Non-Small Cell Lung Cancer.
Research Progress and Challenges in the Treatment of Central Nervous System Metastasis of Non-Small Cell Lung Cancer.
复制标题
非小细胞肺癌中枢神经系统转移治疗的研究进展与挑战。
作者:
Wang B;Guo H;Xu H;Yu H;Chen Y;Zhao G
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and has high morbidity and mortality rates. Central nervous system (CNS) metastasis is one of the most frequent complications in patients with NSCLC and seriously affects the quality of life (QOL) and overall survival (OS) of patients, with a median OS of untreated patients of only 1–3 months. There are various treatment methods for NSCLC CNS metastasis, including surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, which do not meet the requirements of patients in terms of improving OS and QOL. There are still many problems in the treatment of NSCLC CNS metastasis that need to be solved urgently. This review summarizes the research progress in the treatment of NSCLC CNS metastasis to provide a reference for clinical practice.
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DOI:
10.1016/s1470-2045(15)00544-6
发表时间:
2016-03
期刊:
The Lancet. Oncology
影响因子:
--
作者:
Antonia S;Goldberg SB;Balmanoukian A;Chaft JE;Sanborn RE;Gupta A;Narwal R;Steele K;Gu Y;Karakunnel JJ;Rizvi NA
通讯作者:
Rizvi NA
影响因子:
50.5
作者:
Chalabi, M.;Cardona, A.;Herrera, F. G.
通讯作者:
Herrera, F. G.
影响因子:
3.7
作者:
Chang WY;Wu YL;Su PL;Yang SC;Lin CC;Su WC
通讯作者:
Su WC
影响因子:
45.3
作者:
Awad, Mark M.;Oxnard, Geoffrey R.;Sholl, Lynette M.
通讯作者:
Sholl, Lynette M.
影响因子:
2.5
作者:
Afzal, Muhammad Zubair;Dragnev, Konstantin;Shirai, Keisuke
通讯作者:
Shirai, Keisuke