Research Progress and Challenges in the Treatment of Central Nervous System Metastasis of Non-Small Cell Lung Cancer.

Research Progress and Challenges in the Treatment of Central Nervous System Metastasis of Non-Small Cell Lung Cancer.
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非小细胞肺癌中枢神经系统转移治疗的研究进展与挑战。

DOI:
10.3390/cells10102620
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发表时间:
2021-10-01
期刊:
影响因子:
6
通讯作者:
Zhao G
Zhao G
中科院分区:
生物学2区
文献类型:
--
作者:
Wang B;Guo H;Xu H;Yu H;Chen Y;Zhao G

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非小细胞肺癌(Non-small cell lung cancer,NSCLC)是最常见的恶性肿瘤之一,发病率和死亡率都很高。中枢神经系统(CNS)转移是NSCLC患者最常见的并发症之一,严重影响患者的生活质量(QOL)和总生存期(OS),未经治疗的患者中位OS仅为1-3个月。NSCLC CNS转移的治疗方法多种多样,包括手术、化疗、放疗、靶向治疗、免疫治疗等,在改善OS和QOL方面均不能满足患者的要求。NSCLC中枢神经系统转移的治疗仍有许多问题亟待解决。本文就非小细胞肺癌中枢神经系统转移治疗的研究进展进行综述,以期为临床实践提供参考。
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and has high morbidity and mortality rates. Central nervous system (CNS) metastasis is one of the most frequent complications in patients with NSCLC and seriously affects the quality of life (QOL) and overall survival (OS) of patients, with a median OS of untreated patients of only 1–3 months. There are various treatment methods for NSCLC CNS metastasis, including surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, which do not meet the requirements of patients in terms of improving OS and QOL. There are still many problems in the treatment of NSCLC CNS metastasis that need to be solved urgently. This review summarizes the research progress in the treatment of NSCLC CNS metastasis to provide a reference for clinical practice.
杜瓦卢马布(Durvalumab)和非小细胞肺癌中的tremelimumab的安全性和抗肿瘤活性:多中心1B研究。
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