Exploring structure and function of sensory cortex with 7T MRI.
Exploring structure and function of sensory cortex with 7T MRI.
复制标题
用 7T MRI 探索感觉皮层的结构和功能。
DOI：
10.1016/j.neuroimage.2017.01.081
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发表时间：
2018
期刊：
影响因子：
5.7
通讯作者：
Schluppeck D
中科院分区：
文献类型：
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作者：
Schluppeck D
在本文中，我们提出了一个概述的7 T磁共振成像（MRI）研究的详细功能和解剖的感觉区的人脑。我们讨论了研究的动机，特别强调使用减少视野（FOV）数据采集增加功能性MRI（fMRI）的空间分辨率。超高场（UHF）MRI（此处定义为7 T及以上）与较低场强相比具有几个优势。图像的固有信噪比（SNR）在UHF下更高，并且与增加的血氧水平依赖（BOLD）信号变化相结合，这导致增加的BOLD对比噪声比（CNR），其可以被利用来提高空间分辨率或检测较弱的信号。此外，与较低场强相比，来自血管内（IV）隔室的BOLD信号相对减弱。总之，这些特性使7 T功能MRI成为高空间特异性测量的有吸引力的主张。但伴随优势而来的是一些挑战。例如，在EPI采集中，易受磁致伸缩性引起的几何失真和信号损失的脆弱性增加往往要大得多。其中一些技术问题可以用现有的工具解决，我们将对此进行讨论。我们强调在7 T的高分辨率功能和结构成像的关键方法考虑。然后，我们提出了最近的数据，使用高空间分辨率在超高频的视觉和躯体感觉皮层的研究，突出在这一领域有前途的发展。
In this paper, we present an overview of 7 T magnetic resonance imaging (MRI) studies of the detailed function and anatomy of sensory areas of the human brain. We discuss the motivation for the studies, with particular emphasis on increasing the spatial resolution of functional MRI (fMRI) using reduced field-of-view (FOV) data acquisitions. MRI at ultra-high-field (UHF) – defined here as 7 T and above – has several advantages over lower field strengths. The intrinsic signal-to-noise ratio (SNR) of images is higher at UHF, and coupled with the increased blood-oxygen-level-dependent (BOLD) signal change, this results in increased BOLD contrast-to-noise ratio (CNR), which can be exploited to improve spatial resolution or detect weaker signals. Additionally, the BOLD signal from the intra-vascular (IV) compartment is relatively diminished compared to lower field strengths. Together, these properties make 7 T functional MRI an attractive proposition for high spatial specificity measures. But with the advantages come some challenges. For example, increased vulnerability to susceptibility-induced geometric distortions and signal loss in EPI acquisitions tend to be much larger. Some of these technical issues can be addressed with currently available tools and will be discussed. We highlight the key methodological considerations for high resolution functional and structural imaging at 7 T. We then present recent data using the high spatial resolution available at UHF in studies of the visual and somatosensory cortex to highlight promising developments in this area.