Early childhood infection and atopic disorder
Early childhood infection and atopic disorder
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DOI：
10.1136/thx.53.11.927
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发表时间：
1998-11-01
期刊：
影响因子：
10
通讯作者：
Hopkin, JM
中科院分区：
文献类型：
--
作者：
Farooqi, IS;Hopkin, JM
背景-特应性疾病有复杂的原因，但最近西方化社区中特应性疾病的增加表明了重要的环境影响的作用。一种可能的机制是儿童时期微生物暴露模式的变化。这项流行病学研究调查了儿童感染和随后的特应性疾病之间的关系，考虑了一系列社会和医学变量。方法-共有1934名受试者在牛津郡的一家家庭医生诊所进行了研究，这些受试者代表了1975-84年的回顾性出生组。回顾公共卫生和实践记录；所有感染的诊断和治疗、所有免疫接种、哮喘、花粉热和湿疹的诊断；母亲特应性和一些其他变量被记录在案。结果-Logistic回归分析确定了三个对后续特应性疾病有统计学意义的预测因素：母亲特应性(1.97，95%CI 1.46至2.66，P
Background-Atopy is of complex origins but the recent rise in atopic diseases in westernised communities points to the action of important environmental effects. One candidate mechanism is the changing pattern of microbial exposure in childhood. This epidemiological study investigated the relationship between childhood infections and subsequent atopic disease, taking into account a range of social and medical variables.Methods-A total of 1934 subjects representing a retrospective 1975-84 birth group at a family doctor practice in Oxfordshire were studied. Public health and practice records were reviewed; temporal records were made of all diagnoses of infections and their treatments, all immunisations, and diagnoses of asthma, hay fever and eczema; maternal atopy and a number of other variables were documented.Results-Logistic regression analysis identified three statistically significant predictors of subsequent atopic disease: maternal atopy (1.97, 95% CI 1.46 to 2.66, p