Increased amygdala reactivity following early life stress: a potential resilience enhancer role.
Increased amygdala reactivity following early life stress: a potential resilience enhancer role.
复制标题
早期生活压力后杏仁核反应性增加：潜在的弹性增强剂作用。
DOI：
10.1186/s12888-017-1201-x
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发表时间：
2017-01-18
期刊：
影响因子：
4.4
通讯作者：
Yamawaki S
中科院分区：
文献类型：
--
作者：
Yamamoto T;Toki S;Siegle GJ;Takamura M;Takaishi Y;Yoshimura S;Okada G;Matsumoto T;Nakao T;Muranaka H;Kaseda Y;Murakami T;Okamoto Y;Yamawaki S
杏仁核高反应性有时被认为是抑郁症之前的一个脆弱因素;然而，在健康的人中，经历早期生活压力但不会变得抑郁，它可能代表一种弹性机制。我们的目的是检验这些假设，研究与早期生活压力（ELS）史相关的杏仁核活动增加是否与从未抑郁的成年人的抑郁症状和负性生活事件压力的影响呈负相关或正相关。24名健康受试者在功能磁共振成像（fMRI）评估期间完成了一项个性化的负面情绪诱导任务，沿着ELS评估。与未报告ELS的参与者相比，报告ELS的从未抑郁的参与者的情绪变化和杏仁核反应性增加。然而，杏仁核反应性的增加降低了ELS对抑郁症状和负性生活事件应激的影响。在悲伤记忆回忆中，ELS患者的杏仁核反应性与双侧DLPFC、运动皮层和纹状体也有积极的功能联系。ELS患者的杏仁核活动增加与症状减轻和神经功能增加有关，与情绪调节一致，这表明杏仁核反应的保留可能反映了对抑郁和负面压力事件的压力缓冲或弹性增强因素。
Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults. Twenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS. Mood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall. Increased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events.