Cortical Mapping of Naming Errors in Aphasia
Cortical Mapping of Naming Errors in Aphasia
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DOI：
10.1002/hbm.20683
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发表时间：
2009-08-01
影响因子：
4.8
通讯作者：
Moser, Dana
中科院分区：
文献类型：
--
作者：
Fridriksson, Julius;Baker, Julie M.;Moser, Dana
失语症患者的临床特征差异很大；然而，他们都有一个共同的特征--失调症--命名共同物体的障碍。先前的研究已经证明，特定的命名错误与特定的左半球病变有关。然而，我们对大脑保留区域中与失语症言语错误相关的皮质活动知之甚少。利用功能磁共振成像(FMRI)，我们首次发现，在不同类型和严重程度的失语症中，特定的言语错误与共同的皮质活动有关。具体地说，音素错误的产生招募了左侧后外周枕叶和颞叶区域。类似的活动模式与语义错误有关，尽管是在右脑。这项研究并没有贬低左半球中风后皮质活动的可变性；相反，它强调了一组具有共同诊断但临床特征截然不同的患者在大脑调制方面的共性。Hum Brain Mapp 30：2487-2498,2009。(C)2009年Wiley-Liss，Inc.
Persons with aphasia vary greatly with regard to clinical profile; yet, they all share one common feature-anomia-an impairment in naming common objects. Previous research has demonstrated that particular naming errors are associated with specific left hemisphere lesions. However, we know very little about the cortical activity in the preserved brain areas that is associated with aphasic speech errors. Utilizing; functional magnetic resonance imaging (fMRI), we show for the first time that specific speech errors are associated with common cortical activity in different types and severities of aphasia. Specifically, productions of phonemic errors recruited the left posterior Perilesional occipital and temporal lob, areas. A similar pattern of activity was associated with semantic errors, albeit in the right hemisphere. This study does not discount variability in cortical activity following left hemisphere stroke; rather, it highlights commonalities in brain modulation ill a population of patients with a common diagnosis but vastly different clinical profiles. Hum Brain Mapp 30:2487-2498, 2009. (c) 2009 Wiley-Liss, Inc.