Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats
Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats
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DOI：
10.1016/j.homp.2014.08.003
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发表时间：
2015-01
期刊：
影响因子：
1.7
通讯作者：
K. Hanif;M. Kumar;Neetu Singh;R. Shukla
中科院分区：
文献类型：
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作者：
K. Hanif;M. Kumar;Neetu Singh;R. Shukla
研究背景：石松是一种广泛应用于肝脏、泌尿系统和消化系统疾病的顺势疗法药物。最近，在Lycalkaloid提取物中发现了乙酰胆碱酯酶（AchE）抑制活性，这可能对痴呆症有益。目的：探讨Lycon对侧脑室注射链脲佐菌素（STZ）致记忆障碍大鼠学习记忆功能和脑血流量的影响。雄性SD大鼠分别用30、200和1000剂量的苦参酊（MT）处理17天。分别于第14、15、16天用Morris水迷宫实验评价大鼠学习记忆能力。结果：STZ（ICV）治疗组大鼠学习记忆能力下降，脑血流量减少，LycMT和200治疗组大鼠学习记忆能力改善。结论：Lycin对记忆障碍大鼠的脑血流量有明显的改善作用，可作为记忆障碍治疗的首选药物。
Background:Lycopodium clavatum(Lyc) is a widely used homeopathic medicine for the liver, urinary and digestive disorders. Recently, acetyl cholinesterase (AchE) inhibitory activity has been found inLycalkaloid extract, which could be beneficial in dementia disorder. However, the effect ofLychas not yet been explored in animal model of memory impairment and on cerebral blood flow.Aim:The present study was planned to explore the effect ofLycon learning and memory function and cerebral blood flow (CBF) in intracerebroventricularly (ICV) administered streptozotocin (STZ) induced memory impairment in rats.Materials and methods:Memory deficit was induced by ICV administration of STZ (3 mg/kg) in rats on 1st and 3rd day. Male SD rats were treated withLycMother Tincture (MT) 30, 200 and 1000 for 17 days. Learning and memory was evaluated by Morris water maze test on 14th, 15th and 16th day. CBF was measured by Laser Doppler flow meter on 17th day.Results:STZ (ICV) treated rats showed impairment in learning and memory along with reduced CBF.LycMT and 200 showed improvement in learning and memory. There was increased CBF in STZ (ICV) treated rats at all the potencies ofLycstudied.Conclusion:The above study suggests thatLycmay be used as a drug of choice in condition of memory impairment due to its beneficial effect on CBF.