Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue.
Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue.
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DOI：
10.1038/s41467-023-43254-7
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发表时间：
2023-11-27
影响因子：
16.6
通讯作者：
McNaughton, Bruce L
中科院分区：
文献类型：
--
作者：
Chang, HaoRan;Esteves, Ingrid M;Neumann, Adam R;Mohajerani, Majid H;McNaughton, Bruce L
情景记忆包括分布在新皮层区域的各种经验属性。海马体是快速结合这些弥散表征的组成部分，当它们发生时，稍后会恢复。然而，在这种大脑皮层对话过程中交换的信息的性质仍然知之甚少。最近的一项研究表明，次级运动皮层携带两种类型的表征：位置细胞样活动，这是由海马损伤受损，以及与视觉触觉线索有关的反应，这在海马损伤后变得更加明显。使用双光子Ca 2+成像记录雄性Thy 1-GCaMP 6s小鼠次级运动皮层中的神经元活动，我们评估了虚拟环境中先前探索的空间和非空间属性的皮层检索。我们发现，导航后，自发的静息状态再激活传达不同程度的空间（轨迹序列）和非空间（视觉-触觉属性）信息，而非空间属性的再激活往往先于海马尖波波纹周围的空间表征的再激活。情节记忆的机制还不清楚。在这里，作者表明，非空间信息的再激活先于空间信息的再激活，并且两者都与海马尖波波纹相关。
Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study has shown that the secondary motor cortex carries two types of representations: place cell-like activity, which were impaired by hippocampal lesions, and responses tied to visuo-tactile cues, which became more pronounced following hippocampal lesions. Using two-photon Ca2+ imaging to record neuronal activities in the secondary motor cortex of male Thy1-GCaMP6s mice, we assessed the cortical retrieval of spatial and non-spatial attributes from previous explorations in a virtual environment. We show that, following navigation, spontaneous resting state reactivations convey varying degrees of spatial (trajectory sequences) and non-spatial (visuo-tactile attributes) information, while reactivations of non-spatial attributes tend to precede reactivations of spatial representations surrounding hippocampal sharp-wave ripples. The mechanisms of episodic memory are not well understood. Here, the authors show that the reactivation of non-spatial information precedes the reactivation of spatial information, and that both are correlated with hippocampal sharp-wave ripples.