A Review of Cyclophosphamide
A Review of Cyclophosphamide
复制标题
环磷酰胺的综述
DOI：
10.1038/bjc.1975.258
复制
发表时间：
1975
影响因子：
8.8
通讯作者：
B. Fox
中科院分区：
文献类型：
--
作者：
B. Fox
521主要用于复习Fabrikant的淋巴系统功能解剖学。的确，这本书的主要价值在于它的评论和所采用的各种技术，因此它可能证明是一个有用的参考来源。令人遗憾的是，人们不得不等到会议进行到一半时才读到Mendlesohn对恶性组织和正常组织中细胞周期的评估。在这篇优秀的综述中，细胞动力学实验技术和细胞行为的比较都非常强烈地提出了，建议读者首先转向这篇文章。Frindel， Dethlefsen和Valeriote都对放射或药物治疗下的细胞增殖进行了全面研究，从而合理设计了癌症治疗程序。然而，Valeriote是明智的，他认识到细胞群体动力学只是大约24个因素中的一个，他的评论的目的是把肿瘤治疗中的细胞周期分析放在正确的角度上。再一次遗憾的是，这篇论文在会议中姗姗来迟。许多作者对研究具有随机年龄和混合化学成分的异步增殖细胞群所产生的问题表示了合理的关注。因此，他们求助于人工同步的种群（主要是在体外），以期在细胞再次变得不同步之前获得相关信息。读者可以采取他的选择和机会的任何技术，以产生细胞增殖同步。这种条件通常用于生化观察，一些作者证明了酶和环AMP水平与细胞周期阶段相关的显着周期性。对于非生物化学家来说，这组论文可以为诸如环AMP代谢和多胺生物合成等生物化学复杂性提供快速参考点。卡梅隆提出了一篇关于体内有丝分裂控制的分析文章，并提供了大量的例子。他列举了三个层次的控制：(i)一般控制，影响所有的增殖群体；(2)特定控制，针对某些器官、组织或群体；(3)同一群体细胞之间的局部作用。这篇文章消除了偶尔困扰这类工作的障碍，为细胞增殖控制的学生提供了必要的阅读材料。遗憾的是，他忽略了第四种控制，即……细胞之间的局部作用。
521 useful primarily for its review of the functional anatomy of the lymphoid system given by Fabrikant. Indeed, the main value of the volume rests in its reviews and in the variety of techniques employed so that it may prove a useful reference source. It is perhaps a pity that one has to wait until the mid point of the meeting to read Mendlesohn's assessment of the cell cycle in malignant and normal tissues. In this excellent review both the technology of cell kinetics experimentation and comparisons of cell behaviour are brought out very strongly and it is recommended that the reader turns first to this article. Frindel, Dethlefsen and Valeriote all present overall studies of cell proliferation under radiation or drug treatments leading to a rational design of cancer therapeutic procedures. Valeriote, however, is wise in recognizing cell population kinetics as only one of about two dozen factors and the purpose of his review is to put cell cycle analysis in tumour therapy in its proper perspective. Again it is a pity that this paper comes so late in the proceedings. Much legitimate concern is shown by a number of authors over the problems created by studying asynchronously proliferating populations of cells which have a random age and mixed chemical composition. They accordingly resort to artificially synchronized populations (mainly in vitro) in the anticipation of obtaining relevant information before the cells become, once more, asynchronous. The reader may take his choice and chance on any of a number of techniques for producing cell proliferative synchrony. Such conditions were commonly used for the biochemical observations and several authors demonstrate a marked cyclicity of enzyme and cyclic AMP levels related to phases of the cell cycle. To the non-biochemist, this group of papers can provide a quick reference point to such biochemical intricacies as, for example, cyclic AMP metabolism and poly-amine biosynthesis. An analytical essay on mitotic control in the body is presented by Cameron and liberally supported with examples. He cites three levels of control: (i) general, affecting all proliferative populations, (2) specific, for certain organs, tissues or populations and (3) local action between cells of the same population. This article removes the blinkers that have occasionally beset this type of work and makes essential reading for a student 36 of cell proliferation control. Regrettably he omits consideration of a fourth type of control, namely local action between cells of …