A modified Timeline Followback assessment to capture alcohol exposure in pregnant women: Application in the Safe Passage Study
A modified Timeline Followback assessment to capture alcohol exposure in pregnant women: Application in the Safe Passage Study
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DOI：
10.1016/j.alcohol.2017.02.174
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发表时间：
2017-08-01
期刊：
影响因子：
2.3
通讯作者：
Burd, Larry
中科院分区：
文献类型：
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作者：
Dukes, Kimberly;Tripp, Tara;Burd, Larry
产前酒精暴露（PAE）与不良妊娠结局有关，但没有公认的PAE评估标准，并且数量，频率和时间的具体影响在很大程度上仍然未知。安全通道研究旨在调查PAE在连续不良妊娠结局和产后结局中的作用，本文的目的是描述对传统时间轴随访（TLFB）进行修改的基本原理和可行性，以收集大型孕妇队列中的PAE信息。来自北方平原地区（美国）和南非开普敦的受试者采用改良的30天TLFB访谈进行前瞻性随访，最多进行5次，以获得详细的PAE信息。我们人群所需的修改包括捕获有关共享，类型/品牌，容器大小和持续时间的信息，以便准确记录饮酒量。在11，892例入组妊娠中，99.9%在妊娠期间至少定义一次PAE状态，92%在所有妊娠期定义PAE状态。在报告的53，823种饮料中，98%具有标准饮料计算所需的所有项目。据报道，南非开普敦有74%的饮料是共享的，北方平原有10%的饮料是共享的。与传统TLFB的参考值相比，74%和67%的饮料分别具有不同的酒精体积和容器大小。此外，一个统计上显着的差异，发现报告的容器数量和计算的标准饮料的数量，使用修改TLFB的信息。这是第一个将所有这些变化完全纳入单一指标的研究，以便更准确地计算每日消费量并评估一段时间内的模式。用于收集PAE信息和创建酒精暴露措施的方法可能会提高报告的标准饮料的准确性，并可推广到其他人群。(C)2017爱思唯尔公司All rights reserved.
Prenatal alcohol exposure (PAE) has been linked to poor pregnancy outcomes, yet there is no recognized standard for PAE assessment, and the specific effects of quantity, frequency, and timing remain largely unknown. The Safe Passage Study was designed to investigate the role of PAE in a continuum of poor peri- and postnatal outcomes.The objective of this manuscript is to describe the rationale for, and feasibility of, modifications to the traditional Timeline Followback (TLFB) for collecting PAE information in a large cohort of pregnant women. Participants from the Northern Plains region (in the United States) and Cape Town, South Africa, were followed prospectively using a modified 30-day TLFB interview, administered up to five times, to obtain detailed PAE information. Required modifications for our population included capturing information regarding sharing, type/brand, container size, and duration, in order to accurately record the amount of alcohol consumed. PAE status was defined for 99.9% of the 11,892 enrolled pregnancies at least once during pregnancy and for 92% across all trimesters. Of 53,823 drinks reported, 98% had all items necessary for standard drink computation. Sharing was reported for 74% of drinks in Cape Town, South Africa and for 10% in the Northern Plains. Compared to referent values from the traditional TLFB, 74% and 67% of drinks had different alcohol-by-volume and container size, respectively. Furthermore, a statistically significant difference was found between the number of containers reported and the number of standard drinks computed, using information from the modified TLFB. This is the first study of this size to wholly encompass all of these changes into a single measure in order to more accurately calculate daily consumption and assess patterns over time. The methods used to collect PAE information and create alcohol exposure measures likely increased the accuracy of standard drinks reported and could be generalized to other populations. (C) 2017 Elsevier Inc. All rights reserved.