Olfactory Change Pattern after Endoscopic Sinus Surgery in Chronic Rhinosinusitis with Olfactory Dysfunction
Olfactory Change Pattern after Endoscopic Sinus Surgery in Chronic Rhinosinusitis with Olfactory Dysfunction
复制标题
慢性鼻窦炎伴嗅觉障碍内镜鼻窦手术后嗅觉变化模式
DOI：
10.29271/jcpsp.2018.08.612
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Shi Li
中科院分区：
文献类型：
--
作者：
Zi Xiao Xue;Li Zhi Li;Jin Peng;Feng Hui Wei;Zhao Li;Tu Yan Yi;Shi Li
目的：目的探讨慢性鼻窦炎（CRS）伴嗅觉功能障碍患者鼻内镜手术（ESS）后嗅觉功能的变化规律及其与检查评分的关系。..研究设计：观察性研究。..研究地点和时间：山东大学第二医院，2014年12月至2016年1月。..方法学：对34例CRS伴鼻息肉（CRSwNP）和14例CRS不伴鼻息肉（CRSsNP）患者术前进行T&T嗅觉测试、嗅觉VAS测试、SNOT-20评分和Lund-Mackay CT评分。在术后1个月、3个月和6个月重新评价结局。..结果：CRSwNP和CRSsNP组的嗅觉和SNOT-20评分在6个月内均显示出显著改善。T&T试验中嗅觉丧失者改善程度最大。CRSsNP组术后1个月和3个月嗅觉功能无明显恢复。CRSwNP患者的嗅觉评分与CT评分显著相关（r=0.649，p<0.001; r=0.625，p<0.001）。然而，没有发现之间的相关性SNOT-20评分和嗅觉评分术前。..结论：我们的研究已经证实，鼻内窥镜手术对嗅觉功能的治疗效果可持续长达6个月，特别是在CRSwNP患者中。虽然治疗效果在术后3个月达到稳定，但嗅觉功能在3至6个月之间继续恢复。
Objective: To determine the change pattern of olfactory function in chronic rhinosinusitis (CRS) with olfactory dysfunction after endoscopic sinus surgery (ESS), and its association with inspection scores. ..Study Design: Observational study. ..Place and Duration of Study: Second Hospital of Shandong University, China, from December 2014 to January 2016. ..Methodology: Thirty-four CRS with nasal polyps (CRSwNP) patients and 14 CRS without nasal polyps (CRSsNP) patients were evaluated preoperatively by T&T olfactory test, olfactory VAS test, SNOT-20 score and Lund-Mackay CT score. Outcomes were re-evaluated at 1 month, 3 months and 6 months postoperatively. ..Results: Both olfactory and SNOT-20 scores showed significant improvement within 6 months in both CRSwNP and CRSsNP groups. Patients with anosmia in T&T test showed the largest degree of improvement. No significant recovery of olfactory dysfunction was observed at 1 month and 3 months in CRSsNP groups postoperative. In CRSwNP, the olfactory scores were correlated with the CT scores significantly (r=0.649, p<0.001; r=0.625, p<0.001). However, no correlation was found between the SNOT-20 score and olfactory score preoperatively. ..Conclusion: Our study has confirmed that the therapeutic effects of ESS on olfactory function last for up to 6 months, particularly in patients with CRSwNP. Although the therapeutic effects plateaued at 3 months postoperatively, the olfactory function continues to recover between 3 and 6 months.