The interferon response to intracellular DNA: Why so many receptors?
The interferon response to intracellular DNA: Why so many receptors?
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DOI：
10.1016/j.imbio.2013.07.007
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发表时间：
2013-11-01
期刊：
影响因子：
2.8
通讯作者：
Unterholzner, Leonie
中科院分区：
文献类型：
--
作者：
Unterholzner, Leonie
细胞内DNA的检测已经成为对病毒和细胞内细菌的先天免疫应答中以及在无菌炎症和自身免疫条件下的关键事件。将DNA检测为“陌生人”和“危险”信号的后果之一是产生I型干扰素和促炎细胞因子。许多工作一直致力于阐明激活这种DNA诱导的基因表达程序的信号级联。然而，尽管近年来许多蛋白质被提出作为细胞内DNA的传感器，但没有一种蛋白质被普遍接受，而且迄今为止还缺乏一个将所有最近的观察结果联系起来的理论。本文综述了迄今为止提出的各种干扰素诱导DNA受体的证据，并探讨了可能解释为什么这么多不同的受体似乎参与细胞内DNA的先天免疫识别的假设。(C)2013 Elsevier GmbH. All rights reserved.
The detection of intracellular DNA has emerged to be a key event in the innate immune response to viruses and intracellular bacteria, and during conditions of sterile inflammation and autoimmunity. One of the consequences of the detection of DNA as a 'stranger' and a 'danger' signal is the production of type I interferons and pro-inflammatory cytokines. Much work has been dedicated to the elucidation of the signalling cascades that activate this DNA-induced gene expression programme. However, while many proteins have been proposed to act as sensors for intracellular DNA in recent years, none has been met with universal acceptance, and a theory linking all the recent observations is, as yet, lacking. This review presents the evidence for the various interferon-inducing DNA receptors proposed to date, and examines the hypotheses that might explain why so many different receptors appear to be involved in the innate immune recognition of intracellular DNA. (C) 2013 Elsevier GmbH. All rights reserved.