Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver.
复制标题
DOI：
10.4049/jimmunol.1601818
复制
发表时间：
2017-02-15
期刊：
影响因子：
--
通讯作者：
Yokoyama WM
中科院分区：
文献类型：
--
作者：
Aw Yeang HX;Piersma SJ;Lin Y;Yang L;Malkova ON;Miner C;Krupnick AS;Chapman WC;Yokoyama WM
大多数关于NK细胞的知识都是基于对小鼠脾脏或人外周血中传统NK细胞（cNK）的研究。然而，最近对小鼠的研究表明，在某些器官（如肝脏）中存在组织常驻NK （trNK）细胞，与cNK细胞相比，它们表现出不同的标记物和转录因子依赖性。在这里，我们提供了通过飞行时间分析和人源化小鼠的细胞术的证据，表明人类cd49e阴性NK细胞在肝脏中是组织驻留的。因此，这些研究表明trNK细胞在人类和小鼠中具有进化保守性，为探索其在人类疾病中的作用提供了基础。
Most knowledge on NK cells are based on studies of what are now known as conventional NK (cNK) cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK (trNK) cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared to cNK cells. Here we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e-negative NK cells are tissue-resident in the liver. Thus, these studies indicate that trNK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.