Identification of specific microRNA-messenger RNA regulation pairs in four subtypes of breast cancer
Identification of specific microRNA-messenger RNA regulation pairs in four subtypes of breast cancer
复制标题
四种乳腺癌亚型中特定 microRNA-信使 RNA 调控对的鉴定
DOI：
10.1049/iet-syb.2019.0086
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发表时间：
2020-06-01
影响因子：
2.3
通讯作者：
Xiong, Jie
中科院分区：
文献类型：
--
作者：
Guo, Ling;Zhang, Aihua;Xiong, Jie
基于人类肿瘤的基因表达谱，已经鉴定了四种乳腺癌亚型，即管腔型A、管腔型B、基底样、人表皮生长因子受体富集型。本研究的目的是发现是否相同群体的基因在四种亚型之间会表现出不同的网络。鉴定了四种亚型与正常人之间的差异表达基因。四组差异表达基因之间的重叠被用来构建四种亚型中每一种的调控网络。采用单变量和多变量考克斯回归分析来检验四个调控网络中的基因。本研究表明，四种亚型的共同基因表现出不同的调控。此外，hsa-miR-182和核心蛋白聚糖对在乳腺癌的四种亚型中执行不同的功能。结果表明，乳腺癌的异质性不仅体现在不同基因之间表达模式的差异上，而且还体现在同一组基因的调控网络的差异上。
Four subtypes of breast cancer, luminal A, luminal B, basal-like, human epidermal growth factor receptor-enriched, have been identified based on gene expression profiles of human tumours. The goal of this study is to find whether the same groups' genes would exhibit different networks among the four subtypes. Differential expressed genes between each of the four subtypes and the normal samples were identified. The overlaps between the four groups of differentially expressed genes were used to construct regulations networks for each of the four subtypes. Univariate and multivariate Cox regressions were employed to test the genes in the four regulation networks. This study demonstrated that the common genes in four subtypes showed different regulation. Also, the hsa-miR-182 and decorin pair performs different functions among the four subtypes of breast cancer. The result indicated that heterogeneity of breast cancer is not only reflected in the different expression patterns among different genes, but also in the different regulatory networks of the same group of genes.