A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
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DOI：
10.1021/co300060s
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发表时间：
2012-09-01
影响因子：
--
通讯作者：
Houghten, Richard A.
中科院分区：
文献类型：
--
作者：
Giulianotti, Marc A.;Debevec, Ginamarie;Houghten, Richard A.
提出了一种直接评价混合物中化合物等摩尔性的新方法。我们应用该方法计算了树脂结合多肽片段的氨基末端与磺酰氯反应的等速比，以生成等摩尔的磺胺混合物。讨论了本研究的结果以及该方法在合成两个新的位置扫描合成组合文库(PS-SCL)中的应用。
A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.