Synthesis of green-emitting Pt8 nanoclusters for biomedical imaging by pre-equilibrated Pt/PAMAM (G4-OH) and mild reduction
Synthesis of green-emitting Pt8 nanoclusters for biomedical imaging by pre-equilibrated Pt/PAMAM (G4-OH) and mild reduction
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DOI：
10.1364/ome.3.000157
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发表时间：
2013-02-01
影响因子：
2.8
通讯作者：
Inouye, Yasushi
中科院分区：
文献类型：
--
作者：
Tanaka, Shin-ichi;Aoki, Koichi;Inouye, Yasushi
我们用温和的还原剂从预平衡的铂/第四代聚酰胺胺(PAMAM(G4-OH))树枝状大分子(PAMAM(G4-OH))络合物中还原铂离子，合成了绿光发射铂(铂)纳米团簇(激发波长：460 nm，发射波长：520 nm)。用电喷雾电离质谱仪测定了合成的铂纳米团簇Pt8L8(L=C2H2O2S)的结构特征。这些纳米团簇具有28%的量子产率，高于绿色发射的Au和Ag纳米团簇。我们还发现铂纳米团簇具有相当低的细胞毒性和生物相容性，并证明了它们可以用于生物医学成像。本研究提供了将铂纳米团簇的光致发光波长扩展到近红外区域的可能性，这是生物成像应用的理想选择。(C)2013年美国光学学会
We synthesized green-emitting platinum (Pt) nanoclusters (excitation: 460 nm, emission: 520 nm) by reducing Pt ions from pre-equilibrated Pt/fourth-generation poly(amidoamine) dendrimers (PAMAM (G4-OH)) complexes with a mild reductant. The structural characteristics of the resulting Pt nanoclusters, Pt8L8 (L = C2H2O2S), were determined by Electrospray ionization (ESI) mass spectroscopy. These nanoclusters possess a 28% quantum yield, which is higher than those of green-emitting Au and Ag nanoclusters. We also found that Pt nanoclusters have considerably low cytotoxicity and biocompatibility, and demonstrated that they could be used for biomedical imaging. This study provides the possibility to extend the photoluminescent wavelength of Pt nanoclusters to the near infrared region, which is ideal for biological imaging applications. (C) 2013 Optical Society of America