Increased Prevalence of Colorectal Polyp in Acromegaly Patients: A Case-Control Study
Increased Prevalence of Colorectal Polyp in Acromegaly Patients: A Case-Control Study
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肢端肥大症患者结直肠息肉患病率增加：病例对照研究
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
C. Alkim
中科院分区：
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作者：
A. Koksal;M. Ergun;S. Boga;H. Alkim;M. Bayram;Y. Altuntas;Banu Ozguven Yilmaz;C. Alkim
据报道，肢端肥大症患者的结肠直肠息肉和癌症患病率增加。本试验旨在确定土耳其肢端肥大症患者中结直肠息肉/癌症的患病率是否增加。66例患者，谁是在随访诊断肢端肥大症，并进行全结肠镜检查，入组研究。选择65名年龄和性别匹配的非特异性主诉患者作为对照。肢端肥大症患者的平均年龄为51.5 ± 12.8岁，其中27例（40.9%）为女性。在20例（30.3%）肢端肥大症患者中，共检测到65个结直肠息肉。直肠乙状结肠息肉检出率为72.3%。在65例对照组患者中，8例（12.3%）共发现17个息肉，两组之间存在统计学显著差异（P = 0.018）。在logistic回归分析中，我们发现肢端肥大症患者结肠息肉的风险增加3.2倍，与年龄和性别无关（OR：3.191，95%CI：1.25-8.13）。总之，随访诊断为肢端肥大症的患者应接受结肠镜监测计划，并应切除所有检测到的息肉，以保护他们免受结直肠癌的侵害。
An increase in the prevalence of colorectal polyps and cancer is reported in patients with acromegaly. This trial is designed to determine whether there is an increase in the prevalence of colorectal polyps/cancer in Turkish acromegaly patients. Sixty-six patients, who were under follow-up with the diagnosis of acromegaly and underwent total colonoscopic examination, were enrolled in the study. Sixty-five age- and gender-matched patients with nonspecific complaints were selected as control. The mean age of acromegalic patients was 51.5 ± 12.8 years of whom 27 (40.9%) were females. In 20 (30.3%) of the patients with acromegaly a total of 65 colorectal polyps were detected. Forty-seven (72.3%) of the polyps were detected at the rectosigmoid region. In 8 (12.3%) of the 65 control patients a total of 17 polyps were found. There was a statistically significant difference between the groups (P = 0.018). At the logistic regression analysis we found that the risk for colon polyps increased 3.2-fold in the presence of acromegaly, irrespective of age and gender (OR: 3.191, 95% CI: 1.25–8.13). In conclusion, patients who were followed up with the diagnosis of acromegaly should be taken to the colonoscopic surveillance program and all polyps detected should be excised in order to protect them from colorectal cancer.