Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
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DOI：
10.2217/bmm-2021-0989
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发表时间：
2022-03
影响因子：
2.2
通讯作者：
Qin Li;Yanyun Wang;Zhilong Li;Min Su;Yaping Song;Q. Hu;Bin Zhou;Lin Zhang
中科院分区：
文献类型：
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作者：
Qin Li;Yanyun Wang;Zhilong Li;Min Su;Yaping Song;Q. Hu;Bin Zhou;Lin Zhang
目的：卵巢癌是妇科恶性肿瘤，病因复杂，复发率高，预后判断困难。来自IL-6受体家族成员的制瘤素M受体（OSMR）与肿瘤发展相关。本研究旨在探讨OSMR基因多态性（rs 2278329 [G/A，错义，Asp 553 Asn]，rs 2292016 [G/T，启动子，-100G/T]）与OC的相关性。方法：选择160例OC患者和397例健康对照者。采用TaqMan SNP Genotyping Assay对两个单核苷酸多态性位点进行基因分型，并采用SPSS软件进行统计学分析。结果：携带rs 2278329 GA/AA基因型的浆液性卵巢癌患者的总生存率显著降低。同时，rs 2292016的TT基因型携带者的复发率有所提高，GT基因型与较低的复发率显示出明确的相关性。结论：OSMR基因多态性可能与浆液性OC的复发和总生存期有关。
Aim: Ovarian cancer (OC) is a gynecological malignancy with a challenging judgment of prognosis due to complicated etiology and high recurrence rate. The oncostatin M receptor (OSMR) from members of the IL-6 receptor family is associated with tumor development. This study aims to explore the correlations between OSMR gene polymorphisms (rs2278329 [G/A, missense, Asp553Asn], rs2292016 [G/T, promoter, -100G/T]) and OC. Methods: This study enrolled 160 OC patients and 397 healthy controls. Genotypes of two single-nucleotide polymorphisms were distinguished using TaqMan SNP Genotyping Assay, and statistical analysis was performed using SPSS software. Results: A significantly decreased overall survival rate was found in serous OC patients carrying rs2278329 GA/AA genotypes. Meanwhile, TT genotype carriers of rs2292016 had an improved relapse rate, and the GT genotype showed a definitive correlation with a lower relapse rate. Conclusion: OSMR gene polymorphisms may be related to recurrence and overall survival of serous OC patients.