White matter in autism spectrum disorders - evidence of impaired fiber formation
White matter in autism spectrum disorders - evidence of impaired fiber formation
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DOI：
10.1258/ar.2011.110197
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发表时间：
2011-12-01
期刊：
影响因子：
1.3
通讯作者：
Nikkinen, Juha
中科院分区：
文献类型：
--
作者：
Bode, Michaela K.;Mattila, Marja-Leena;Nikkinen, Juha
背景：扩散张量成像（DTI）可以测量和显示神经纤维束的显微结构。现有的文献对自闭症谱系障碍（ASD）和DTI是异质性的方法和结果。目的：比较脑白色物质的高功能个体与ASD和对照。材料和方法：基于束的空间统计（TBSS）是一种基于体素的DTI方法，用于比较27名ASD受试者（平均年龄14.7岁，范围11.4-17.6岁，20名男孩，7名女孩）和26名对照受试者（平均年龄14.5岁，范围11.7-17.3岁，17名男孩，9名女孩）。创建平均各向异性分数（FA）图像（骨架），然后将每个受试者的对齐FA数据投影到该骨架上。体素跨学科的统计数据的统计分析的FA数据，平均扩散率（MD），扩散方向的措施进行了计算。重要的是，数据校正整个图像，而不是使用ROI为基础的methods.Results：ASD组显示显着更大的FA（P < 0.05，校正），在该地区包含集群的视辐射和右下额枕束（iFOF）。在同一区域，ASD组的λ（3）（代表横向扩散）显著降低。结论：iFOF内的横向扩散减少与岛叶显著性加工区和枕叶视觉区之间的异常信息流有关。
Background: Diffusion tensor imaging (DTI) enables measurements and visualization of the microstructure of neural fiber tracts. The existing literature on autism spectrum disorders (ASDs) and DTI is heterogenous both regarding methodology and results.Purpose: To compare brain white matter of high-functioning individuals with ASDs and controls.Material and Methods: Tract-based spatial statistics (TBSS), a voxel-based approach to DTI, was used to compare 27 subjects with ASDs (mean age 14.7 years, range 11.4-17.6 years, 20 boys, 7 girls) and 26 control subjects (mean age 14.5 years, range 11.7-17.3 years, 17 boys, 9 girls). Mean fractional anisotropy (FA) image (skeleton) was created and each subject's aligned FA data were then projected onto this skeleton. Voxelwise cross-subject statistics on the skeletonized FA data, mean diffusivity (MD), and measures of diffusion direction were calculated. Importantly, the data were corrected across the whole image instead of using ROI-based methods.Results: The ASD group showed significantly greater FA (P < 0.05, corrected) in the area containing clusters of optic radiation and the right inferior fronto-occipital fasciculus (iFOF). In the same area, lambda(3) (representing transverse diffusion) was significantly reduced in the ASD group. No age-related changes were found.Conclusion: The results suggest that the reduced transverse diffusion within the iFOF is related to abnormal information flow between the insular salience processing areas and occipital visual areas.