Diminished medial prefrontal cortex activity in blood-injection-injury phobia
Diminished medial prefrontal cortex activity in blood-injection-injury phobia
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DOI：
10.1016/j.biopsycho.2007.01.002
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发表时间：
2007-05-01
影响因子：
2.6
通讯作者：
Schienle, Anne
中科院分区：
文献类型：
--
作者：
Hermann, Andrea;Schaefer, Axel;Schienle, Anne
We examined the effects of symptom induction on neural activation in blood-injection-injury (BII) phobia. Nine phobic and 10 non-phobic subjects participated in an fMRI study in which they were presented with disorder-relevant, generally disgust-inducing, generally fear-evoking and neutral pictures. We observed diminished medial prefrontal cortex (MPFC) activity in patients compared to controls for phobia-relevant and disgust-inducing pictures. The MPFC has been shown to be critically involved in the automatic and effortful cognitive regulation of emotions. Therefore, the results might reflect reduced cognitive control of emotions in BII phobics during the experience of phobic symptoms as well as during states of disgust. The latter response component might be a result of the elevated disgust sensitivity of BII phobics. (C) 2007 Elsevier B.V. All rights reserved.
