Structure-activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A.

Structure-activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A.
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白喉毒素和铜绿假单胞菌外毒素 A 的构效关系。

DOI:
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发表时间:
1988
影响因子:
--
通讯作者:
R. Collier
R. Collier
中科院分区:
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文献类型:
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作者:
R. Collier

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尽管原则上没有理由可以将几种杀细胞细菌毒素中的任何一种用于免疫毒素构建,但迄今为止只有两种这样的毒素被广泛用于此目的,即白喉毒素(DT)和铜绿假单胞菌外毒素A(PE)。白喉毒素是这一领域工作者的早期关注焦点,因为当时有关于这种特殊毒素的结构和活性的详细信息。由于目前还没有针对PE的疫苗,因此PE比DT更受青睐。本文综述了这两种毒素的结构和活性。
Although there is no reason in principle why any of several cytocidal bacterial toxins might be used for immuntoxin construction, only two such toxins have been employed extensively to date for this purpose, namely, diphtheria toxin (DT) and Pseudomonas aeruginosa exotoxin A (PE). Diphtheria toxin was an early focus of workers in this area because of the detailed information available at that time on the structure and activity of this particular toxin. Recently PE has been favored over DT by some because of the fact that there has been no vaccine against it. Here the structure and activity of these two toxins is reviewed.
DOI: 10.1016/s0021-9258(19)70365-2
发表时间: 1980-11
期刊: The Journal of biological chemistry
影响因子: --
作者:
B. Ness;J. Howard;James W. Bo y
通讯作者: B. Ness;J. Howard;James W. Bo y
DOI: 10.1021/bi00341a027
发表时间: 1985-01-01
期刊: BIOCHEMISTRY
影响因子: 2.9
作者:
BLEWITT, MG;CHUNG, LA;LONDON, E
通讯作者: LONDON, E
DOI: --
发表时间: 1985
期刊: The Journal of biological chemistry
影响因子: --
作者:
Tweten,RK;Barbieri,JT;Collier,RJ
通讯作者: Collier,RJ
假单胞菌外毒素 A。膜结合、插入和穿越。
DOI: --
发表时间: 1986
期刊: The Journal of biological chemistry
影响因子: --
作者:
Farahbakhsh,ZT;Baldwin,RL;Wisnieski,BJ
通讯作者: Wisnieski,BJ
DOI: 10.1073/pnas.78.8.4950
发表时间: 1981-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
KAGAN, BL;FINKELSTEIN, A;COLOMBINI, M
通讯作者: COLOMBINI, M