A debut for mito-mouse
A debut for mito-mouse
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Mito-mouse 首次亮相
作者：
E. Shoubridge
无法构建由突变的线粒体DNA（mtDNA）引起的人类疾病的动物模型一直是研究与特定mtDNA突变相关的发病机制的主要障碍。现在已经产生了携带线粒体DNA大规模缺失的小鼠。它们显示了人类疾病的一些关键特征，但也有令人惊讶的差异。
The inability to construct animal models of human diseases caused by mutated mitochondrial DNA (mtDNA) has been a major obstacle to investigating pathogenetic mechanisms associated with specific mtDNA mutations. Mice carrying a large-scale deletion in mtDNA have now been produced. They display some of the key features of the human disorder, but there are surprising differences.