Anticancer Activity of Polyether Ionophore-Salinomycin
Anticancer Activity of Polyether Ionophore-Salinomycin
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DOI：
10.2174/1871520615666150101130209
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Huczynski, Adam
中科院分区：
文献类型：
--
作者：
Antoszczak, Michal;Huczynski, Adam
自从发现天然聚醚抗生素-盐霉素的不同寻常的抗肿瘤活性以来，这种化合物及其衍生物已经在体内和体外对不同的人类癌细胞进行了深入的研究。Salinomycin对多种不同癌细胞的增殖过程显示出较强的抑制活性，包括耐多药（MDR）癌细胞，以及癌症干细胞（CSCs），即白血病干细胞、结肠癌干细胞、前列腺癌干细胞等。此外，盐霉素的应用已被证明可以增强放化疗的抗癌效果。初步临床研究显示，应用盐碱霉素后，肿瘤消退，只有短暂的急性副作用。目前，人们对盐碱霉素抗肿瘤活性的生物学机制进行了大量的研究，希望这些研究结果能够为盐碱霉素活性的生物学调控提供新的治疗策略。本文综述了盐霉素在癌症治疗中的可能作用，并对其性质进行了综述。
Since the discovery of unusual anti-tumor activity of natural polyether antibiotic - Salinomycin, this compound, along with its derivatives, has been intensively studied against different human cancer cells, both in vivo and in vitro. Salinomycin has shown strong inhibition activity against the proliferation process of many different cancer cells, including multi-drug resistance (MDR) cancer cells, as well as cancer stem cells (CSCs), i.e. leukemic stem cells, colon carcinoma stem cells, prostate cancer stem cells and many others. Additionally, the application of Salinomycin has been proved to enhance the anti-cancer effect of radio- and chemotherapy. Preliminary clinical studies have shown tumor regression and only transient acute side effects after application of Salinomycin. Up to now, major efforts have been devoted to elucidate the biological mechanisms of anti-tumor activity of Salinomycin and it is expected that the results may provide new therapeutic strategies based on biological modulation of Salinomycin activity. This review is focused on and describes the possible role of Salinomycin in cancer therapy and gives an overview of its properties.