Cortical correlates of perceptual decision making during tactile spatial pattern discrimination
Cortical correlates of perceptual decision making during tactile spatial pattern discrimination
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DOI：
10.1002/hbm.22844
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发表时间：
2015-09-01
影响因子：
4.8
通讯作者：
Braun, Christoph
中科院分区：
文献类型：
--
作者：
Hegner, Yiwen Li;Lindner, Axel;Braun, Christoph
知觉决策涉及一个分布式大脑皮层网络，包括与感觉特征提取、决策形成以及最终通过运动反应发出决策信号相关的区域。尽管这些处理步骤被认为是按顺序进行的，但感知决定与运动反应的似乎即时映射使得这些过程几乎无法区分。为了将与感觉决策相关的皮质区域从准备后续运动反应的区域中分离出来，我们在具有交错的即时和延迟反应条件的触觉空间模式辨别任务中进行了功能磁共振成像。通过在触觉模式中添加空间噪声，对决策难度进行了参数控制，导致决策时间随着噪声的增加而增加。我们假设，参与做出决定的区域应该表现出它们的激活随着决定时间的变化而变化，无论(即时反应条件)或(延迟反应条件)是否可以提前准备好运动反应。为了展示这些假定的决定区域，我们使用即时反应条件下的反应时间作为参数预测因子，以预测两种反应条件下血氧水平依赖(BOLD)活性的难度依赖变化。右侧(对侧)中央后沟、右侧顶内沟(IPS)和双侧前岛(ANS)的BOLD激活在两种反应条件下都反映了这种参数调制，表明这些区域在独立于决策特定运动准备的触觉决定中发挥作用。此外，对单一难度水平延迟反应条件下的大胆反应进行了多变量模式分析，独立地验证了IPS和ANS是决策相关领域。Hum Brain Mapp 36：3339-3350,2015。(C)2015年威利期刊公司。
Perceptual decision making involves a distributed cortical network including areas related to sensory feature extraction, decision formation, and finally signalling the decision through a motor response. Although these processing steps are supposed to occur in sequence, the seemingly instant mapping of a perceptual decision onto a motor response renders these processes almost indistinguishable. To dissociate cortical areas related to sensory decision making from areas that prepare the subsequent motor response, we performed functional magnetic resonance imaging during a tactile spatial pattern discrimination task with interleaved immediate and delayed response conditions. Decision difficulty was manipulated parametrically by adding spatial noise to the tactile patterns, resulting in a rise in decision time with increasing noise. We assumed that areas involved in making the decision should show a variation in their activation with decision time and irrespective of whether (immediate response condition) or not (delayed response condition) a motor response could be prepared in advance. To exhibit these putative decision areas, we used response time, as was obtained in the immediate response condition, as parametric predictor for the difficulty-dependent variations of blood oxygenation level-dependent (BOLD)-activity in both response conditions. BOLD activations in right (contralateral) postcentral sulcus, right intraparietal sulcus (IPS) and bilateral anterior insula (aINS) reflected this parametric modulation in both response conditions, suggesting a role of these areas in tactile decisions independent of decision-specific motor preparation. Furthermore, a multivariate pattern analysis performed on the BOLD responses in the delayed response condition for a single difficulty level independently validated IPS and aINS as decision-related areas. Hum Brain Mapp 36:3339-3350, 2015. (c) 2015 Wiley Periodicals, Inc.