Squalene-hopene cyclase: catalytic mechanism and substrate recognition
Squalene-hopene cyclase: catalytic mechanism and substrate recognition
复制标题
DOI：
10.1039/b108995c
复制
发表时间：
2002-01-01
影响因子：
4.9
通讯作者：
Sato, T
中科院分区：
文献类型：
--
作者：
Hoshino, T;Sato, T
角鲨烯环化酶是近几年才出现的一种新型的环化酶，其催化机理和底物识别研究进展迅速。一系列定点突变实验和一些角鲨烯类似物结合X射线晶体数据的信息，为多环化机制和催化位点提供了深入的见解。
Rapid progress on the catalytic mechanism and substrate recognition by squalene-hopene cyclase, which has occurred only in the last several years, is reported. A series of site-directed mutation experiments and some squalene analogues have provided deep insight into the polycyclization mechanism and catalytic sites in conjunction with the information from X-ray crystal data.