Peritumoral brain edema volume in meningioma correlates with tumor fractional anisotropy but not apparent diffusion coefficient or cerebral blood volume
Peritumoral brain edema volume in meningioma correlates with tumor fractional anisotropy but not apparent diffusion coefficient or cerebral blood volume
复制标题
脑膜瘤的瘤周脑水肿体积与肿瘤各向异性分数相关，但与表观扩散系数或脑血容量无关
作者：
C. Toh;M. Castillo
脑膜瘤瘤周脑水肿（PTBE）的发病机制尚不清楚。PTBE体积与脑膜瘤扩散或灌注特性之间的关系尚未研究。我们的目的是研究脑膜瘤的扩散和灌注特性是否与其PTBE体积相关。回顾性分析了70例连续的脑膜瘤患者（平均年龄，58.9 ± 13.7岁; 37名女性），他们术前进行了DTI和DSC-PWI。测量PTBE体积、肿瘤体积、肿瘤的平均T2信号、ADC、FA和CBV。比较有无PTBE脑膜瘤患者的年龄、性别、T2信号强度、肿瘤体积、ADC值、FA值和CBV值。在脑膜瘤PTBE中，分析PTBE体积与患者年龄和性别的相关性，以及肿瘤的T2信号强度、体积、ADC、FA和CBV。进行多变量线性回归分析，以确定与PTBE体积相关的因素。单因素分析显示，无PTBE的脑膜瘤多见于女性（P = 0.033），表现为较低的ADC（P = 0.020）、较高的FA（P <0.001）和较低的CBV（P <0.001）。脑膜瘤的PTBE体积与肿瘤ADC（r = 0.444; P = 0.001）、肿瘤FA（r =-0.655; P <0.001）和肿瘤CBV（r = 0.402; P = 0.003）相关。在多因素分析中，肿瘤FA是唯一与PTBE体积相关的因素（P <0.001）。脑膜瘤的PTBE体积与肿瘤FA相关。DTI有助于了解脑膜瘤PTBE的发生机制。
Pathogenesis of peritumoral brain edema (PTBE) in meningiomas remains unclear. Associations between PTBE volume and diffusion or perfusion properties of meningioma have not been studied. We aimed to investigate if diffusion and perfusion properties of meningioma correlate with its PTBE volume. Seventy consecutive patients (mean age, 58.9 ± 13.7 years; 37 women) with meningiomas who had preoperative DTI and DSC-PWI were retrospectively analyzed. PTBE volume, tumor volume, and mean T2 signal, ADC, FA, and CBV of the tumor were measured. Between meningiomas with and without PTBE, patient age and sex, as well as T2 signal intensity, volume, ADC, FA, and CBV of tumors, were compared. In meningiomas with PTBE, correlations of PTBE volume with patient age and sex, as well as T2 signal intensity, volume, ADC, FA, and CBV of tumors, were analyzed. Multivariable linear regression analysis was performed to identify factors associated with PTBE volume. On univariable analysis, meningiomas without PTBE were more frequently found in women (P = 0.033) and demonstrated lower ADC (P = 0.020), higher FA (P < 0.001), and lower CBV (P < 0.001). PTBE volume of meningiomas correlated with tumor ADC (r = 0.444; P = 0.001), tumor FA (r = − 0.655; P < 0.001), and tumor CBV (r = 0.402; P = 0.003). On multivariable analysis, tumor FA was the only factor associated with PTBE volume (P < 0.001). PTBE volume in meningioma correlates with tumor FA. DTI may help to understand the mechanism of PTBE in meningiomas.
影响因子：
2.8
作者：
Batalov, A., I;Afandiev, R. M.;Pronin, I. N.
通讯作者：
Pronin, I. N.