Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand?
Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand?
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DOI：
10.4252/wjsc.v3.i1.1
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发表时间：
2011-01-26
影响因子：
4.1
通讯作者：
Camara, Niels Olsen Saraiva
中科院分区：
文献类型：
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作者：
Bassi, Enio Jose;Aita, Carlos Alberto Mayora;Camara, Niels Olsen Saraiva
多能间充质基质细胞（Multipotent mesenchymal stromal cells，MSC）可以从几乎所有的单个身体组织中分离和有效扩增，具有自我更新和分化为各种中胚层细胞谱系的能力。此外，这些细胞被认为是免疫特权的，与缺乏完全T细胞活化所需的共刺激分子的表面表达有关。近年来，研究发现MSC可通过抑制树突状细胞的成熟，抑制自身免疫性疾病和炎症性疾病中T淋巴细胞、B淋巴细胞和自然杀伤细胞的功能，从而抑制免疫应答，成为免疫抑制的新策略。MSC的免疫调节机制的理解是必要的，它们作为免疫疗法在临床应用中的几种疾病。
Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of surface expression of costimulatory molecules required for complete T cell activation. Recently, it has been observed that MSC are capable of suppressing the immune response by inhibiting the maturation of dendritic cells and suppressing the function of T lymphocytes, B lymphocytes and natural killer cells in autoimmune and inflammatory diseases as a new strategy for immunosuppression. The understanding of immune regulation mechanisms by MSC is necessary for their use as immunotherapy in clinical applications for several diseases.