Amount of satellite DNA in four experimentally induced tumors of the central nervous system. Quantitative changes in a glioblastoma producing C-type particles.
Amount of satellite DNA in four experimentally induced tumors of the central nervous system. Quantitative changes in a glioblastoma producing C-type particles.
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四种实验诱导的中枢神经系统肿瘤中卫星 DNA 的量。
DOI：
10.1093/jnci/56.1.43
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
E. E. Manuelidis
中科院分区：
文献类型：
--
作者：
L. Manuelidis;E. E. Manuelidis
卫星NA的定量保存在几个中枢神经系统（CNS）肿瘤进行了研究;四个肿瘤线deriveo从3-甲基胆蒽植入到中枢神经系统的小鼠进行了比较与正常小鼠细胞的脑和组织培养物，通过分析离心在氯化铯。三种肿瘤与正常细胞没有可检测到的差异;核和全细胞制备物相当。只有一株产生C型颗粒的胶质母细胞瘤细胞系（TC 509）显示出与正常细胞显著的差异，在一年的重复检测中，卫星DNA减少约20%或总DNA的2%。C型RNA病毒可能与在TC 509中观察到的卫星DNA的相对减少有关。
The quantitative preservation of satellite NA was studied in several central nervous system (CNS) neoplasms; four tumor lines deriveo from 3-methylcholanthrene implantation into the CNS of mice were compared with brain and tissue cultures of normal mouse cells by analytical centrifugation in cesium chlorie. Three tumors showed no detectable difference from normal cells; nuclear and whole cell preparations were comparable. Only a glioblastoma line proucing C-type particles (TC509) revealed a significant difference from normal cells and exhibited a decrease of approximately 20% in satellite DNA or 2% of the total DNA on repeated examination for 1 year. C-type RNA virus may be related to relative decreases in satellite DNA observed in TC509.