Gastrointestinal Targeted Sampling and Sensing via Embedded Packaging of Integrated Capsule System
Gastrointestinal Targeted Sampling and Sensing via Embedded Packaging of Integrated Capsule System
复制标题
DOI：
10.1109/jmems.2019.2897246
复制
发表时间：
2019-04-01
影响因子：
2.7
通讯作者：
Ghodssi, Reza
中科院分区：
文献类型：
--
作者：
Banis, George E.;Beardslee, Luke A.;Ghodssi, Reza
在这里，我们介绍了一个无线平台，该平台利用各种胃肠道（GI）分泌物的生化特性，选择性地溶解用作3d打印生物相容性胶囊涂层的ph敏感聚合物，使液体进入包含电容传感器的传感室。可消化胶囊技术在自主进入胃肠道区域的普及程度越来越高，否则需要临床干预。我们的平台使用带有传感器的3.3 v电源运行，具有0.3-220 pF动态范围，灵敏度为3.2 x 10(-3) pF/mV，将电容变化传递给智能系统级封装，然后通过低功耗蓝牙传输到外部Android手机。该系统与各种聚合物进行了测试，这些聚合物用于制药工业，以控制特定pH曲线的不同GI区域的溶解。这种实时、经济、用户友好的平台最终将用于测试对胃肠道分泌物中特定生物标志物有反应的替代涂层材料，为增强肠道诊断提供了巨大的潜力。(2018 - 0249)
Here, we introduce a wireless platform developed to leverage biochemical characteristics of various gastrointestinal (GI) secretions to selectively dissolve pH-sensitive polymers used as coatings over a 3-D printed biocompatible capsule, allowing fluid entry into sensing chambers containing capacitive sensors. Ingestible capsule technology is increasing prevalence in autonomously accessing regions of GI that otherwise require clinical intervention. Our platform is operated using a 3.3-V power source with sensors, possessing a 0.3-220-pF dynamic range with a sensitivity of 3.2 x 10(-3) pF/mV that relay the change in capacitance to a smart system-in-package, which is then transmitted via Bluetooth low energy to an external Android phone. The system is tested with a variety of polymers, which are used in the pharmaceutical industry, to control dissolution at different GI regions characteristic of a specific pH profile. This real-time, cost-effective, and user-friendly platform will ultimately be used to test alternative coating materials that respond to specific biomarkers present in GI secretions, offering significant potential for enhancing gut diagnostics. [2018-0249]