Effect of phase locking AC and RF voltages for high mass analysis in a quadrupole ion trap mass spectrometer.
Effect of phase locking AC and RF voltages for high mass analysis in a quadrupole ion trap mass spectrometer.
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DOI：
10.1002/rcm.1290101502
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发表时间：
2006-06
期刊：
影响因子：
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通讯作者：
V. Doroshenko;R. Cotter
中科院分区：
文献类型：
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作者：
V. Doroshenko;R. Cotter
在低β z弹射值下，对四极离子阱质谱仪进行了交流和射频相位锁定对质谱质量分辨率和谱线位置的影响实验，探讨了利用这种效应进行高质量分析的可能性。在典型的质量扫描速率为1000 u/s时，在β z = 0.25时，质量分辨率的提高不超过10-20%，而在β z = 0.5时，质量分辨率的提高为200-250%。然而，在没有锁相的情况下，β z = 0.25时的质量分辨率大约是β z = 0.5时的两倍。因此，在β z = 0.25时观察到的无锁相AC和RF频率的质量分辨率的绝对值与在β z = 0.5时观察到的锁相质量分辨率的绝对值大致相同。这一观察结果可以用离子微振荡在射频基频沿轨迹的质量分辨率显著负贡献来解释，这与β z = 0.25和β z = 0.5的情况不同。
Experiments on the influence of locking the AC and RF frequency phases on the mass resolution and line position in the mass spectra from a quadrupole ion trap mass spectrometer were carried out at low ejection values of beta z to investigate the possibility of using this effect for high mass analysis. At a typical mass scan rate of 1000 u/s the improvement for the mass resolution in these experiments did not exceed 10-20% at beta z = 0.25 compared with 200-250% at beta z = 0.5. However, without phase locking, the mass resolution at beta z = 0.25 was about two times higher than that at beta z = 0.5. Thus, the absolute values for the mass resolution observed without phase-locked AC and RF frequencies at beta z = 0.25 were about the same as at beta z = 0.5 with phase locking. This observation was explained by a significant negative contribution to the mass resolution of the ion microoscillations along the trajectory at the fundamental RF frequency which is different for the cases of beta z = 0.25 and beta z = 0.5.