Homocysteine thiolactone is a positive effector of sigma(S) levels in Escherichia coli.
Homocysteine thiolactone is a positive effector of sigma(S) levels in Escherichia coli.
复制标题
同型半胱氨酸硫代内酯是大肠杆菌中 sigma(S) 水平的正效应子。
DOI：
10.1111/j.1574-6968.2000.tb09048.x
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发表时间：
2000
影响因子：
2.1
通讯作者：
Kolter,R
中科院分区：
文献类型：
--
作者：
Goodrich-Blair,H;Kolter,R
σSis a regulator of the stationary phase response inEscherichia coli. Multi-copy suppressors were sought in a strain with decreased levels of σSand one such suppressor was found to encode HsrA, a putative efflux pump. Multi-copy expression ofhsrAwas shown to lead to accumulation of homocysteine, which is predicted to cause an increase in homocysteine thiolactone (HCTL) levels. A direct correlation between HCTL levels and σSaccumulation was observed both in mutants and during normal cell growth, leading to the hypothesis that HCTL is a physiologically relevant positive effector of σSlevels in vivo.
