Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis.
Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis.
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DOI：
10.4103/0975-3583.95359
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发表时间：
2012-04-01
影响因子：
--
通讯作者：
Chen, Hongying
中科院分区：
文献类型：
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作者：
Chu, Hongxia;Yang, Jun;Chen, Hongying
目的：肿瘤坏死因子- α (tnf - α)基因可能在冠心病（CHD）和心肌梗死（MI）风险中起重要作用。最近，关于tnf - α基因G-308 A （rs1800629）多态性与冠心病/心肌梗死之间的关系，有一些有争议的结果被报道。我们在此研究了中国汉族人群样本中tnf - α基因G-308 a （rs1800629）多态性与冠心病/心肌梗死之间的可能关联。材料和方法：我们检测了535名不相关的中国冠心病患者、420名心肌梗死患者和1020名无冠状动脉疾病对照者的tnf - α G-308 A （rs1800629）基因型。此外，对先前所有关于tnf - α G-308 a多态性与冠心病和心肌梗死风险的研究进行了荟萃分析。结果：tnf - α基因G-308 A （rs1800629）多态性中的AA基因型在冠心病/心肌梗死患者中并不比在对照组中更频繁地发生；校正常规危险因素后，冠心病的优势比（95%置信区间）为1.743(0.325 ~ 1.423)，心肌梗死的优势比为1.731（0.442 ~ 1.526）。对年龄、性别和其他心血管危险因素的进一步分层并没有改变先前的阴性结果。23项研究的汇总荟萃分析也发现，在遗传加性、显性和隐性模型中，tnf - α多态性与冠心病/心肌梗死风险之间没有统计学上的显著关联。亚组分析显示，在亚洲和高加索人群中，tnf - α多态性与冠心病/心肌梗死之间没有关联。结论：本研究显示中国汉族人群中tnf - α基因G-308 A （rs1800629）多态性（等位基因的存在）与冠心病/心肌梗死无相关性。没有证据表明rs1800629的风险效应在白种人和亚洲人之间存在差异。
OBJECTIVES: The tumor necrosis factor-alpha (TNF-alpha) gene may play an important role in coronary heart disease (CHD) and myocardial infarction (MI) risk. Recently, controversial results regarding the association of the G-308 A (rs1800629)polymorphism of the TNF-alpha gene with CHD/MI have been reported. We herein examine a possible association between the G-308 A (rs1800629)polymorphism of the TNF-alpha gene and CHD/MI in a sample of the Chinese Han population.MATERIALS AND METHODS: We determined the genotypes of TNF-alpha G-308 A (rs1800629) in 535 unrelated Chinese patients with CHD, 420 patients with MI, and 1020 coronary artery disease-free controls. Additionally, a meta-analysis of all previous studies on the TNF-alpha G-308 A polymorphism and the risk of CHD and MI was performed.RESULTS: AA genotypes in the G-308 A (rs1800629)polymorphism of the TNF-alpha gene did not occur more frequently in CHD/MI patients than in controls; odds ratios (95% confidence intervals) were 1.743 (0.325 to 1.423) for CHD and 1.731 (0.442 to 1.526) for MI, after adjusting for conventional risk factors. Further stratification for age, gender, and other cardiovascular risk factors did not alter the prior negative findings. Pooled meta-analysis of 23 studies also found no statistically significant associations between the TNF-alpha polymorphism and CHD/MI risk in the genetic additive, dominant, and recessive models. Subgroup analyses showed no association between the TNF-alpha polymorphism and CHD/MI in Asian and Caucasian populations.CONCLUSION: Our study showed no association between the G-308 A (rs1800629) polymorphism of the TNF-alpha gene (presence of A allele) and CHD/MI in the Chinese Han population. There was no evidence of a difference in risk effects of rs1800629 between Caucasians and Asians.