LIMBIC PATHWAYS AND HYPOTHALAMIC NEUROTRANSMITTERS MEDIATING ADRENOCORTICAL RESPONSES TO NEURAL STIMULI
LIMBIC PATHWAYS AND HYPOTHALAMIC NEUROTRANSMITTERS MEDIATING ADRENOCORTICAL RESPONSES TO NEURAL STIMULI
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DOI：
10.1016/0149-7634(94)00062-6
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发表时间：
1995-06-01
影响因子：
8.2
通讯作者：
WEIDENFELD, J
中科院分区：
文献类型：
--
作者：
FELDMAN, S;CONFORTI, N;WEIDENFELD, J
与应激反应相关的主要现象之一是下丘脑-垂体-肾上腺皮质（HPA）轴的激活。该轴由下丘脑室旁核（PVN）中的促肾上腺皮质激素释放因子-41组成，该因子在各种刺激下被释放到门静脉循环中，刺激垂体ACTH分泌，随后刺激肾上腺皮质放电。激活的机制并不统一，对各种刺激的反应是由不同的神经通路介导的。由于下丘脑外边缘结构在HPA功能中起着重要的作用，因此本文旨在描述海马、隔、杏仁核与下丘脑之间的神经通路与肾上腺皮质活动的关系，以及内侧前脑束的不同作用，以及各种下丘脑脱音对神经冲动向下丘脑传递的影响。此外，去甲肾上腺素和血清素在HPA轴激活中的重要性将被描述。
One of the major phenomena related to the stress response is the activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. This axis consists of corticotropin releasing factor-41 in the paraventricular nucleus of the hypothalamus (PVN), which in response to a variety of stimuli is released into the portal circulation and stimulates pituitary ACTH secretion and subsequently adrenocortical discharge. The mechanisms involved in the activation are not uniform and the responses to various stimuli are mediated by different neural pathways. Since extrahypothalamic limbic structures play a significant role in the HPA function, it is the purpose of this review to describe the neural pathways between the hippocampus, septum and amygdala and the hypothalamus in relation to adrenocortical activity and the differential role of the medial forebrain bundle as well as the effects of various hypothalamic deafferentation on the transmission of the neural impulses to the hypothalamus. Also, the importance of norepinephrine and serotonin in the activation of the HPA axis will be delineated.