Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia
Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia
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DOI：
10.1176/appi.ajp.163.5.927
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发表时间：
2006-05-01
影响因子：
17.7
通讯作者：
Brown, AS
中科院分区：
文献类型：
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作者：
Babulas, V;Factor-Litvak, P;Brown, AS
目的：在这项出生队列研究中，作者研究了产前暴露于母体生殖/生殖（G/R）感染和子代精神分裂症之间的关系。方法：出生队列由7,794名孕妇的后代组成，前瞻性地获得了产科记录中母体G/R感染的数据。作者在该队列中诊断了71例精神分裂症和其他精神分裂症谱系障碍。母亲G/R感染和精神分裂症的风险之间的关系modeled.Results：暴露于G/R感染围受孕期与精神分裂症和其他精神分裂症谱系障碍的风险显着增加，调整母亲的种族，教育，年龄，和精神疾病。结论：母亲G/R感染围受孕期出现精神分裂症的风险增加的后代。
Objective: In this birth cohort study, the authors examined the relation between prenatal exposure to maternal genital/reproductive (G/R) infections and schizophrenia in offspring.Method: The birth cohort consisted of 7,794 offspring of pregnancies with prospectively acquired data on maternal G/R infections from obstetric records. The authors diagnosed 71 cases of schizophrenia and other schizophrenia spectrum disorders in this cohort. The relationship between maternal G/R infections and schizophrenia risk was modeled.Results: Exposure to G/R infections during the periconceptional period was associated with a significantly increased risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness.Conclusions: Maternal G/R infection during periconception appears to increase the risk of schizophrenia in offspring.