Measurement of fetal fat in utero in normal and diabetic pregnancies using magnetic resonance imaging
Measurement of fetal fat in utero in normal and diabetic pregnancies using magnetic resonance imaging
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DOI：
10.1002/uog.12382
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发表时间：
2013-09-01
影响因子：
7.1
通讯作者：
Mansell, P.
中科院分区：
文献类型：
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作者：
Anblagan, D.;Deshpande, R.;Mansell, P.
目的评估磁共振成像（MRI）的可靠性，以测量胎儿脂肪体积在子宫内，并研究胎儿生长的妇女与非糖尿病的巨大儿在former.Methods的患病率增加，我们研究了26例孕妇，14例与妊娠前糖尿病和12例非糖尿病对照。在妊娠24周时进行胎儿评估，并在34周时再次通过标准超声生物测量法进行评估，然后在1.5T下进行MRI。使用基于像素强度并考虑部分体积效应的半自动方法，从T1加权水抑制图像确定胎儿脂肪体积。还根据MRI图像确定胎儿体积。结果妊娠24周时胎儿脂肪含量很少，但妊娠34周时，糖尿病孕妇胎儿脂肪含量显著增加，平均脂肪含量为1090 +/-417 cm（3），对照组为541 +/-348 cm（3）（P=0.006）。胎儿脂肪体积的测量结果显示，在34周时，观察者内和观察者间的变异性较低，组内相关系数始终高于0.99。体重百分位数与胎儿脂肪体积相关（R-2=0.496，P
Objectives To assess the reliability of magnetic resonance imaging (MRI) to measure fetal fat volume in utero, and to study fetal growth in women with and without diabetes in view of the increased prevalence of macrosomia in the former.Methods We studied 26 pregnant women, 14 with pre-gestational diabetes and 12 non-diabetic controls. Fetal assessment took place at 24 weeks' gestation and again at 34 weeks by standard ultrasound biometry followed by MRI at 1.5T. Fetal fat volume was determined from T1-weighted water-suppressed images using a semi-automated approach based on pixel intensity and taking into account partial volume effects. Fetal volume was also determined from the MRI images. Fetal weight was calculated using published fat and lean tissue densities.Results There was little fetal fat at 24 weeks' gestation, but at 34 weeks the fetal fat content was considerably higher in the women with diabetes, with a mean fat content of 1090 +/- 417cm(3) compared with 541 +/- 348cm(3) in the controls (P=0.006). Measurements of fetal fat volume showed low intra- and interobserver variability at 34 weeks, with intraclass correlation coefficients consistently above 0.99. Birth-weight centile correlated with fetal fat volume (R-2=0.496, P