Iron acquisition systems in the pathogenic Neisseria
Iron acquisition systems in the pathogenic Neisseria
复制标题
致病性奈瑟菌中的铁获取系统
DOI：
10.1046/j.1365-2958.1999.01411.x
复制
发表时间：
1999
影响因子：
3.6
通讯作者：
I. Stojiljković
中科院分区：
文献类型：
--
作者：
A. Schryvers;I. Stojiljković
致病性奈瑟氏菌有一系列高亲和力的铁摄取系统，以促进在人类宿主中获得这一基本元素。它们具有直接结合细胞外宿主铁结合蛋白转铁蛋白和乳铁蛋白的表面受体蛋白。或者，它们有铁载体受体，当有外源铁载体存在时，能够清除铁。细胞内释放的铁以血红蛋白、血红蛋白-结合珠蛋白或游离血红素的形式存在，通过与特定的表面受体直接结合，可以直接用作生长的铁源。尽管这些受体的复杂性和组成可能不同，但参与铁(如铁、血红素或铁铁载体)跨外膜运输的关键蛋白是一种依赖于TonB的受体，其总体结构可能与最近确定的大肠杆菌FhuA或FepA相似。鉴于受体在宿主存活中的关键作用，它们可能是理想的疫苗靶标。初步初步研究表明，基于转铁蛋白受体的疫苗可能对人类具有保护作用。
Pathogenic neisseriae have a repertoire of high‐affinity iron uptake systems to facilitate acquisition of this essential element in the human host. They possess surface receptor proteins that directly bind the extracellular host iron‐binding proteins transferrin and lactoferrin. Alternatively, they have siderophore receptors capable of scavenging iron when exogenous siderophores are present. Released intracellular haem iron present in the form of haemoglobin, haemoglobin–haptoglobin or free haem can be used directly as a source of iron for growth through direct binding by specific surface receptors. Although these receptors may vary in complexity and composition, the key protein involved in the transport of iron (as iron, haem or iron‐siderophore) across the outer membrane is a TonB‐dependent receptor with an overall structure presumably similar to that determined recently for Escherichia coli FhuA or FepA. The receptors are potentially ideal vaccine targets in view of their critical role in survival in the host. Preliminary pilot studies indicate that transferrin receptor‐based vaccines may be protective in humans.