Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort.
Comorbid Autoimmune Diseases in Patients With Myasthenia Gravis: A Retrospective Cross-Sectional Study of a Chinese Cohort.
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重症肌无力患者合并自身免疫性疾病：中国队列的回顾性横断面研究
DOI：
10.3389/fneur.2021.790941
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发表时间：
2021
影响因子：
3.4
通讯作者：
Zhao C
中科院分区：
文献类型：
--
作者：
Shi J;Huan X;Zhou L;Xi J;Song J;Wang Y;Luo S;Zhao C
重症肌无力（MG）患者并发自身免疫性疾病（ADs）的现象引起了人们的广泛关注。然而，很少有研究调查中国MG队列中ad的负担和潜在的临床关联。方法：回顾性分析2013年8月至2020年8月复旦大学华山医院1132例MG患者的临床资料。排除病历不完整的患者（n = 336）。结果：796例MG患者中有92例（11.6%）存在ad合并症，其中以甲状腺功能亢进（6.7%）、甲状腺功能减退（2.6%）和白癜风（0.8%）为主。MG合并ad的患者以女性为主，MG症状发病时较年轻，胸腺瘤的发生率较低。与一般人群相比，我们发现甲状腺功能亢进（增加8.5倍，p < 0.001）、甲状腺功能减退（增加2.6倍，p < 0.001）、白癜风（增加1.3倍，p < 0.001）、类风湿关节炎（增加1.4倍，p < 0.001）、免疫性血小板减少性紫癜（增加193.1倍，p < 0.001）、自身免疫性溶血性贫血（增加7.4倍，p < 0.001）、自身免疫性肝炎（增加5.1倍，p < 0.001）和多发性肌炎（增加11.5倍）的比例显著增加。MG合并ad患者既往MC病史的比例低于无ad患者（0比5.6%,p < 0.05）。MG合并ad患者发病时MGFA I类比例显著高于无ad患者（77.0比52.7%,p < 0.05）。MG合并ad患者的musk阳性比例显著低于MG不合并ad患者（0比4.8%,p < 0.05）。结论：总之，我们观察到中国MG队列中并发ad的频率更高。此外，MG合并ad的临床表现往往较轻。
Introduction: The phenomenon of coexisting autoimmune diseases (ADs) in patients with myasthenia gravis (MG) has attracted considerable attention. However, few studies have investigated the burden and potential clinical associations of ADs in Chinese MG cohorts. Methods: In this retrospective cross-sectional study, we reviewed the records of 1,132 patients with MG who were admitted to Huashan Hospital Fudan University from August 2013 to August 2020. Patients were excluded if they had incomplete medical records (n = 336). Results: Comorbid ADs were found in 92 of 796 Chinese patients with MG (11.6%), among which, hyperthyroidism (6.7%), hypothyrosis (2.6%), and vitiligo (0.8%) were predominant. Patients with MG with ADs were predominantly female, younger at the onset of MG symptoms, and had a lower frequency of thymoma. Compared to the general population, we found a significantly higher percentage of hyperthyroidism (8.5-fold increase, p < 0.001), hypothyrosis (2.6-fold increase, p < 0.001), vitiligo (1.3-fold increase, p < 0.001), rheumatoid arthritis (1.4-fold increase, p < 0.001), immune thrombocytopenic purpura (193.1-fold increase, p < 0.001), autoimmune hemolytic anemia (7.4-fold increase, p < 0.001), autoimmune hepatitis (5.1-fold increase, p < 0.001), and polymyositis (11.5-fold increase, p < 0.001) in patients with MG with ADs. Patients with MG with ADs presented a lower proportion of previous history of MC (0 vs. 5.6%, p < 0.05) than those without ADs. The proportion of MGFA Class I at onset in patients with MG with ADs was significantly higher than that in patients with MG without ADs (77.0 vs. 52.7%, p < 0.05). The proportion of MuSK-positive in patients with MG with ADs was significantly lower than that in patients with MG without ADs (0 vs. 4.8%, p < 0.05). Conclusion: In conclusion, we observed a higher frequency of concurrent ADs in a Chinese MG cohort. Furthermore, MG combined with ADs tended to have mild clinical presentation.
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影响因子：
11.1
作者：
Fang, F.;Sveinsson, O.;Piehl, F.
通讯作者：
Piehl, F.
影响因子：
3.9
作者：
Dresser L;Wlodarski R;Rezania K;Soliven B
通讯作者：
Soliven B
影响因子：
3.5
作者：
Chen, Y-L;Yeh, J-H;Chiu, H-C
通讯作者：
Chiu, H-C
深入的外周 CD4( ) T 谱与肌无力危象相关
影响因子：
5.3
作者：
Huan X;Luo S;Zhong H;Zheng X;Song J;Zhou L;Lu J;Wang Y;Xu Y;Xi J;Zou Z;Chen S;Zhao C
通讯作者：
Zhao C
影响因子：
3.4
作者：
Lazaridis K;Tzartos SJ
通讯作者：
Tzartos SJ