The murine autologous mixed lymphocyte response: distribution of stimulator cells.
The murine autologous mixed lymphocyte response: distribution of stimulator cells.
复制标题
小鼠自体混合淋巴细胞反应：刺激细胞的分布。
DOI：
10.1006/jaut.1995.0002
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Hobbs,MV
中科院分区：
文献类型：
--
作者：
Riggs,JE;Sirken,GR;Prior,LG;Hobbs,MV
以前的研究表明，当与同基因的成人脾B细胞共培养时，新生小鼠胸腺T细胞增殖，但成年小鼠不是。有证据表明，在克隆删除或功能失活(无能)之前，这种自我反应性T细胞的扩张。这一机制可能对建立外周(胸腺外)耐受具有特别重要的意义。为了评估不同淋巴组织中B细胞的自刺激能力，用Peyer‘s补片和腹膜细胞培养新生儿T细胞。结果表明，这些组织中的B细胞容易诱导T细胞增殖。有证据表明，B-1B细胞亚群在这一过程中并不是必需的。幼鼠的脾中有明显的自身反应性T细胞，证实了B细胞在维持外周耐受中的作用。结果提示，参与这一过程的B细胞分布于多种淋巴器官中。
Previous studies have shown that neonatal, but not adult, murine thymic T cells proliferate when co-cultured with syngeneic, adult splenic B cells. Evidence suggests that expansion of such self-reactive T cells precedes their clonal deletion or functional inactivation (anergy). This mechanism may be of particular significance for establishing peripheral (extrathymic) tolerance. In order to assess the autostimulatory capacity of B cells present in a variety of lymphoid tissues, neonatal T cells were cultured with Peyer's patch and peritoneal cavity cells. The results indicate that B cells in these tissues readily induce T cell proliferation. Evidence suggests that the B-1 B cell subpopulation is not obligatory for this process. Self-reactive T cells were evident in the spleen of young mice, substantiating a role for B cells in maintaining peripheral tolerance. The results suggest that B cells involved in this process are distributed in a variety of lymphoid organs.