Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats
Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats
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DOI：
10.1016/j.jep.2007.06.022
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发表时间：
2007-09-05
影响因子：
5.4
通讯作者：
Gong, B. Q.
中科院分区：
文献类型：
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作者：
Ji, W.;Gong, B. Q.
正常脂质水平的维持涉及肝脏X受体α（LXR α）和法美奈德X受体（FXR）诱导的基因的参与。本研究旨在评价三七正丁醇提取物（NE 3）的降血脂作用。F.H.并通过动物实验探讨其可能的作用机制。在反式激活试验中，NE 3被鉴定为双重FXR/LXR α激动剂。随后，用NE 3或单独的媒介物经口处理高脂肪/高胆固醇饮食的Sprague-Dawley雄性大鼠。不同浓度NE 3处理组大鼠血清TC、TG、LDL-C水平与对照组比较差异有显著性（P
Maintenance of normal lipid levels has implicated the involvement of genes induced by liver X receptor alpha (LXR alpha) and Famesoid X receptor (FXR). This study was designed to evaluate the hypolipidemic effects of n-butanol extract (NE3) of Panax notoginseng (Burk.) F.H. Chen root on lipid homeostasis and investigate the possible mechanisms in animal experiments. In the transactivation assays, NE3 was identified as a dual FXR/LXR alpha agonist. Subsequently, Sprague-Dawley male rats on a high-fat/high-cholesterol diet were treated orally with NE3 or vehicle alone. As expected, the concentrations of serum TC, TG and LDL-C in rats treated with various concentrations of NE3 showed significant (P