Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.
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DOI：
10.1084/jem.20082468
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发表时间：
2009-05-11
期刊：
影响因子：
--
通讯作者：
Reina-San-Martin B
中科院分区：
文献类型：
--
作者：
Robert I;Dantzer F;Reina-San-Martin B
Immunoglobulin class switch recombination (CSR) is initiated by DNA breaks triggered by activation-induced cytidine deaminase (AID). These breaks activate DNA damage response proteins to promote appropriate repair and long-range recombination. Aberrant processing of these breaks, however, results in decreased CSR and/or increased frequency of illegitimate recombination between the immunoglobulin heavy chain locus and oncogenes like c-myc. Here, we have examined the contribution of the DNA damage sensors Parp1 and Parp2 in the resolution of AID-induced DNA breaks during CSR. We find that although Parp enzymatic activity is induced in an AID-dependent manner during CSR, neither Parp1 nor Parp2 are required for CSR. We find however, that Parp1 favors repair of switch regions through a microhomology-mediated pathway and that Parp2 actively suppresses IgH/c-myc translocations. Thus, we define Parp1 as facilitating alternative end-joining and Parp2 as a novel translocation suppressor during CSR.
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影响因子：
14.9
作者：
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4
作者：
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影响因子：
15.3
作者：
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通讯作者：
Schrader, Carol E.
影响因子：
4.8
作者：
Borggrefe, T;Wabl, M;Jessberger, R
通讯作者：
Jessberger, R
内部 IgH 类开关区缺失与位置无关，并因 AID 表达而增强
DOI：
10.1073/pnas.152333499
发表时间：
2002-07-23
影响因子：
11.1
作者：
Dudley, DD;Manis, JP;Alt, FW
通讯作者：
Alt, FW