Sarcoma-like mural nodules in mucinous cystic tumors of the ovary revisited -: A clinicopathologic analysis of 10 additional cases
Sarcoma-like mural nodules in mucinous cystic tumors of the ovary revisited -: A clinicopathologic analysis of 10 additional cases
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DOI：
10.1097/00000478-200211000-00009
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发表时间：
2002-11-01
影响因子：
5.6
通讯作者：
Prat, J
中科院分区：
文献类型：
--
作者：
Bagué, S;Rodríguez, IM;Prat, J
本文报告十例卵巢黏液性囊性肿瘤，肿瘤内有肉瘤样壁结节。用常规方法和免疫组化方法对结节进行研究。肉瘤样壁结节主要发生在中年女性，多发，与邻近的粘液性肿瘤明显分界，体积小，细胞群异质。这些病变与真正的肉瘤样结节和未分化癌灶的区别是很重要的，因为后两种肿瘤的预后较差，而肉瘤样附壁结节的预后较好。有随访信息的8例患者中有6例存活，平均随访时间为12年，临床上无复发。两名患者死于其他原因（甲状腺癌和乳腺癌）。结核的性质尚不清楚。肉瘤样壁结节可能代表瘤形成中的反应性和自限性现象。它们的波形蛋白和细胞角蛋白的共表达是一致的，从submesothelium间充质细胞，经历部分转化成上皮细胞的起源。
Ten mucinous cystic ovarian tumors that contained sarcoma-like mural nodules are described. The nodules were studied by conventional and immunohistochemical methods. The sarcoma-like mural nodules occurred predominantly in middle-aged women, were multiple and sharply demarcated from the adjacent mucinous tumor, had small size, and exhibited a heterogeneous cell population. Distinction of these lesions from true sarcomatous nodules and foci of anaplastic carcinoma is important because of the worse prognosis of the two latter tumors compared with the favorable behavior of the sarcoma-like mural nodules. Six of the eight patients with follow-up information were alive and clinically free of recurrence at a mean follow-up interval of 12 years. Two patients died of other causes (thyroid and breast carcinomas). The nature of the nodules is not clear. Sarcoma-like mural nodules probably represent a reactive and self-limited phenomenon within a neoplasia. Their coexpression of vimentin and cytokeratins is consistent with an origin from submesothelial mesenchymal cells, which undergo partial transformation into epithelial cells.