Neural correlates of 'distracting' from emotion during autobiographical recollection
Neural correlates of 'distracting' from emotion during autobiographical recollection
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DOI：
10.1093/scan/nsu039
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发表时间：
2015-02-01
影响因子：
4.2
通讯作者：
Dolcos, Florin
中科院分区：
文献类型：
--
作者：
Denkova, Ekaterina;Dolcos, Sanda;Dolcos, Florin
回忆情感自传体记忆（AM）对情感健康很重要，而AM回忆过程中情绪调节（ER）的作用的研究与理解心理健康问题有关。虽然在了解ER和AM的脑机制方面取得了重大进展，但对ER在AM回忆中的作用知之甚少。本研究探讨了如何集中（或“分心”）从情绪内容在上午回忆影响的主观重新体验的情绪和相关的神经相关性，通过操纵检索重点的参与者记住情绪上午，而功能磁共振成像数据记录。首先，注意力远离情绪会导致自我报告的情绪反应减少，沿着的是ER相关区域（腹内侧前额叶皮层，vmPFC）的参与增加，以及情绪相关区域（杏仁核，AMY）的活动减少。第二，在非情绪焦点期间，增加的vmPFC活动与降低的情绪评级有关。第三，中介分析确定vmPFC作为一个功能枢纽整合情感信号从AMY和调解其影响的主观再体验的情绪，根据目前的检索焦点。总的来说，这些发现揭示了在AM回忆期间有效地将注意力从情绪转移开的能力的神经机制，并与理解、预防和治疗情感障碍直接相关，其特征是调节情绪的能力降低。
Remembering emotional autobiographical memories (AMs) is important for emotional well-being, and investigation of the role of emotion regulation (ER) during AM recollection has relevance for understanding mental health issues. Although significant progress has been made in understanding the brain mechanisms underlying ER and AM, less is known about the role of ER during AM recollection. The present study investigated how focusing away (or 'distracting') from the emotional content during AM recollection influences the subjective re-experiencing of emotions and the associated neural correlates, by manipulating the retrieval focus of participants who remembered emotional AMs while fMRI data were recorded. First, focusing away from emotion led to decreased self-reported emotional responses, along with increased engagement of ER-related regions (ventro-medial prefrontal cortex, vmPFC), and reduced activity in emotion-related regions (amygdala, AMY). Second, increased vmPFC activity was linked to reduced emotional ratings, during the non-emotional focus. Third, mediation analysis identified vmPFC as a functional hub integrating affective signals from AMY and mediating their impact on the subjective re-experiencing of emotion, according to the current retrieval focus. Collectively, these findings shed light on the neural mechanisms underlying the ability to effectively switch attentional focus away from emotions during AM recollections and have direct relevance for understanding, preventing and treating affective disorders, characterised by reduced ability to regulate emotions.