High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil
High-sensitivity TMS/fMRI of the Human Motor Cortex Using a Dedicated Multichannel MR Coil
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DOI：
10.1016/j.neuroimage.2017.02.062
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发表时间：
2017-04-15
期刊：
影响因子：
5.7
通讯作者：
Windischberger, Christian
中科院分区：
文献类型：
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作者：
de Lara, Lucia I. Navarro;Tik, Martin;Windischberger, Christian
用途：为了验证一种新的设置，在人类运动皮层的同时TMS/fMRI，基于一个专用的，超薄的，多通道接收MR线圈定位在头皮和TMS系统之间，与标准的鸟笼线圈设置相比，提供了大大增强的灵敏度。方法：在初级运动皮层上应用组合TMS/fMRI设计，基于1Hz刺激，刺激水平为80%、90%、100%，和个体主动运动阈值的110%。由于使用了多通道接收线圈，我们能够使用多频带加速（MB=2）EPI序列采集功能图像。数据进行了分析与SPM 12和BOLD加权信号强度的时间过程中提取每个主题从两个局部最大值（个人功能的手指敲击定位器，固定MM坐标的手旋钮）旁边的手区的初级运动皮层（M1）和从全球maxim.Results：我们报告优秀的图像质量没有明显的信号脱落或图像失真。三个峰值体素中的参数估计值显示随着刺激强度的增加，激活水平单调上升。在所有受试者中，80%、90%、100%、110%的个体主动运动阈值的平均BOLD信号变化分别为0.43%、0.63%、1.01%、2.01%（接近个体功能性手指敲击最大值）、0.73%、0.91%、1.34%、2.21%（接近MM定义的手旋钮）和0.88%，结论：我们的研究结果表明，新的设置并行TMS/fMRI实验使用一个专用的MR线圈阵列允许高灵敏度的fMRI，特别是在现场的刺激。与标准的鸟笼方法相反，结果还表明，新的线圈可以成功地用于多频带加速EPI采集。由于新线圈的灵活性的增益可以很容易地与MR扫描仪内的神经导航相结合，以允许在TMS/fMRI实验中准确定位。
Purpose: To validate a novel setup for concurrent TMS/fMRI in the human motor cortex based on a dedicated, ultra-thin, multichannel receive MR coil positioned between scalp and TMS system providing greatly enhanced sensitivity compared to the standard birdcage coil setting.Methods: A combined TMS/fMRI design was applied over the primary motor cortex based on 1 Hz stimulation with stimulation levels of 80%, 90%, 100%, and 110% of the individual active motor threshold, respectively. Due to the use of a multichannel receive coil we were able to use multiband-accelerated (MB=2) EPI sequences for the acquisition of functional images. Data were analysed with SPM12 and BOLD-weighted signal intensity time courses were extracted in each subject from two local maxima (individual functional finger tapping localiser, fixed MM coordinate of the hand knob) next to the hand area of the primary motor cortex (M1) and from the global maximum.Results: We report excellent image quality without noticeable signal dropouts or image distortions. Parameter estimates in the three peak voxels showed monotonically ascending activation levels over increasing stimulation intensities. Across all subjects, mean BOLD signal changes for 80%, 90%, 100%, 110% of the individual active motor threshold were 0.43%, 0.63%, 1.01%, 2.01% next to the individual functional finger tapping maximum, 0.73%, 0.91%, 1.34%, 2.21% next to the MM-defined hand knob and 0.88%, 1.09%, 1.65%, 2.77% for the global maximum, respectively.Conclusion: Our results show that the new setup for concurrent TMS/fMRI experiments using a dedicated MR coil array allows for high-sensitivity fMRI particularly at the site of stimulation. Contrary to the standard birdcage approach, the results also demonstrate that the new coil can be successfully used for multibandaccelerated EPI acquisition. The gain in flexibility due to the new coil can be easily combined with neuronavigation within the MR scanner to allow for accurate targeting in TMS/fMRI experiments.