Bilirubin production after supplemental oral vitamin E therapy in preterm infants.
Bilirubin production after supplemental oral vitamin E therapy in preterm infants.
复制标题
早产儿补充口服维生素 E 治疗后胆红素的产生。
DOI：
10.1097/00005176-198502000-00008
复制
发表时间：
1985
影响因子：
2.9
通讯作者：
Stevenson,DK
中科院分区：
文献类型：
--
作者：
Smith,DW;Cohen,RS;Vreman,HJ;Yeh,A;Sharron,S;Stevenson,DK
The purpose of this investigation was to determine the influence of early vitamin E supplementation on the rate of heme catabolism (bilirubin production) in healthy preterm infants. Bilirubin production was estimated from the concentration of carbon monoxide in “end‐tidal” gas. Serum vitamin E, hemoglobin, and bilirubin levels were determined by standard techniques. Thirty infants received supplementation with vitamin E or placebo in a double‐blind, randomized fashion. Infants were studied on day 1 of life prior to therapy, and on days 3 and 7 postnatally. Results showed that in both placebo‐supplemented and vitamin E‐supplemented groups, vitamin E levels were significantly higher on days 3 and 7 compared with day 1. Bilirubin production was not significantly different on day 3 compared with day 1 in either group, but was significantly lower in both groups by day 7 compared with day 1. There were no significant differences in hemoglobin and serum bilirubin levels between the two groups at any point in time. In conclusion, although vitamin E supplementation significantly raises vitamin E levels, placebo‐supplemented premature infants also achieve vitamin E sufficiency and a decrease in bilirubin production by day 7 of age.
