CELLULAR MECHANISM FOR PROTECTIVE EFFECT OF HAEMOGLOBIN-S AGAINST P-FALCIPARUM MALARIA
CELLULAR MECHANISM FOR PROTECTIVE EFFECT OF HAEMOGLOBIN-S AGAINST P-FALCIPARUM MALARIA
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DOI：
10.1038/274701a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
WILSON, RJM
中科院分区：
文献类型：
--
作者：
PASVOL, G;WEATHERALL, DJ;WILSON, RJM
对于镰状细胞基因的杂合携带者来说，针对恶性疟原虫的相对保护现在已成为该基因在疟疾流行（或曾经）常见的地区出现频率较高的公认机制1-3。然而，Hb S 保护红细胞免受疟疾寄生虫侵害的细胞机制仍不完全清楚。我们比较了 P 的入侵和生长率。在有氧条件和氧张力降低的条件下，恶性疟原虫明对正常红细胞和镰状细胞病患者的红细胞有影响。作为这些研究的结果，我们提出了一种保护镰状细胞杂合子免受疟原虫感染的可能机制。恶性疟疾。
RELATIVE protection againstPlasmodium falciparummalaria afforded to heterozygous carriers of the sickle-cell gene is now the accepted mechanism for the high frequency of the gene in areas where malaria is (or was) common1–3. However, the cellular mechanisms whereby Hb S protects the red cell against the malarial parasite are still not fully understood. We have compared the rates of invasion and growth ofP. falciparumin normal red cells and in those of individuals with the sickling disorders, in both aerobic conditions and conditions of reduced oxygen tension. As a result of these studies, we suggest a possible mechanism for the protection of sickle-cell heterozygotes againstP. falciparummalaria.