Effect of haemodialysis on immune response.
Effect of haemodialysis on immune response.
复制标题
血液透析对免疫反应的影响。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
J. Bhat
中科院分区：
文献类型：
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作者：
E. Gombos;D. Jefferson;J. Bhat
尿毒症通过改变细胞对有丝分裂原和抗原刺激的反应性来抑制免疫反应。人们可能会认为，通过透析改善尿毒症会改善免疫反应。我们研究了血液透析对体外细胞免疫指标的影响。我们的数据表明，血液透析会导致尿毒症和正常血浆中DNA合成所必需的一个或多个因子的丢失。我们的数据并不表明细胞免疫测量在监测慢性尿毒症患者血液透析充分性方面是有用的。
Uraemia depresses immune response by altering cellular reactivity to mitogenic and antigenic stimulation. One might expect that amelioration of uraemia by dialysis would improve immune responses. We have investigated the effect of haemodialysis on in-vitro parameters of cellular immunity. Our data suggest that haemodialysis leads to loss of a factor or factors from both uraemic and normal plasma essential for DNA synthesis. Our data do not suggest that measurements of celluar immunity are useful in monitoring adequacy of haemodialysis in chronic uraemic patients.